Patents by Inventor Jeremy Michael Baskin
Jeremy Michael Baskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220202837Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: February 15, 2022Publication date: June 30, 2022Inventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Patent number: 11278554Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: October 7, 2019Date of Patent: March 22, 2022Assignee: The Regents of the University of CaliforniaInventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Publication number: 20200046742Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: October 7, 2019Publication date: February 13, 2020Inventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Patent number: 10434111Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: February 12, 2016Date of Patent: October 8, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Publication number: 20160243135Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: February 12, 2016Publication date: August 25, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Patent number: 9260371Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: April 23, 2013Date of Patent: February 16, 2016Assignee: The Regents of the University of CaliforniaInventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Patent number: 8461298Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: August 30, 2010Date of Patent: June 11, 2013Assignee: The Regents of the University of CaliforniaInventors: Carolyn R. Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin
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Patent number: 8431558Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: March 14, 2008Date of Patent: April 30, 2013Assignee: The Regents of the University of CaliforniaInventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
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Publication number: 20110213123Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: August 30, 2010Publication date: September 1, 2011Inventors: Carolyn R. Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin
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Patent number: 7807619Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: October 31, 2005Date of Patent: October 5, 2010Assignee: The Regents of the University of CaliforniaInventors: Carolyn R. Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin
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Publication number: 20090068738Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: March 14, 2008Publication date: March 12, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: CAROLYN RUTH BERTOZZI, NICHOLAS J. AGARD, JENNIFER A. PRESCHER, JEREMY MICHAEL BASKIN, ELLEN MAY SLETTEN