Abstract: The present invention generally relates to an electrostatic coating system for spraying a stream of particles onto a medium, and in particular to a system comprising one or more apparatuses equipped with a powder coating suspension device. What is also contemplated is the use of a powder management system configured to supply predetermined powdered and air mixtures to the apparatus and a controller configured to adjust parameters of operation of both the apparatus and the powder management system. The present disclosure relates to an in-line industrial device able to coat paint, starch, thermoplastic materials, or any other powder material onto a medium by successively controlling a plurality of parameters.

Abstract: Provided, inter alia, are macrocyclic compounds.

Abstract: The present invention generally relates to an electrostatic coating system for spraying a stream of particles onto a medium, and in particular to a system comprising one or more apparatuses equipped with a powder coating suspension device. What is also contemplated is the use of a powder management system configured to supply predetermined powdered and air mixtures to the apparatus and a controller configured to adjust parameters of operation of both the apparatus and the powder management system. The present disclosure relates to an in-line industrial device able to coat paint, starch, thermoplastic materials, or any other powder material onto a medium by successively controlling a plurality of parameters.

Abstract: The invention relates to an ATR spectrometer for analysing the chemical composition of a sample, wherein the ATR spectrometer (1) comprises an ATR crystal (2), at least one infrared light source (5) being arranged on the entry surface (3), a line array (6) of infrared light detectors, at least one single infrared light detector (7), wherein the at least one infrared light source (5) is adapted to emit infrared light that enters the ATR crystal and is guided to the infrared light detectors under total internal reflection and under interaction with the sample being arranged immediately adjacent to the ATR crystal, a wavelength dispersive element (8) being arranged in the path of the infrared light so—that the line array is adapted to measure a spectrum of the infrared light, and a wavelength filter (9) being arranged in the path of the infrared light to the single infrared light detector, wherein at least one of the infrared light detectors is chosen to be a chosen infrared light detector for a signal correctio

Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: A spectral anomaly detection method includes the steps of segmenting a panchromatic image, obtained from a hyperspectral sensor into cluster data sets. Principal component analysis can be separately performed on each of the cluster data sets to produce a plot of principal components. An anomaly detection algorithm can be applied to an adaptively selected subset of principal components for each of the cluster data sets to produce cluster detection scores. Finally, separate detection thresholding algorithms can be applied to each of the cluster detection scores, and the results of the detection thresholding algorithms can be combined into a single detection plane.

Abstract: A spectral anomaly detection method includes the steps of segmenting a panchromatic image, obtained from a hyperspectral sensor into cluster data sets. Principal component analysis can be separately performed on each of the cluster data sets to produce a plot of principal components. An anomaly detection algorithm can be applied to an adaptively selected subset of principal components for each of the cluster data sets to produce cluster detection scores. Finally, separate detection thresholding algorithms can be applied to each of the cluster detection scores, and the results of the detection thresholding algorithms can be combined into a single detection plane.

Abstract: The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.