Patents by Inventor Jeremy N. Gollub

Jeremy N. Gollub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Circulating miRNA biomaker signatures
    Patent number: 9708643
    Abstract: Methods for diagnosis and surveillance of complex multi-factorial disorders such as cancer by screening of easily accessible biomarkers are disclosed. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations in CNA levels are strong predictors of the utility of this biomarker class as clinical indicators. Methods for using microRNAs (miRNAs) representing a class of naturally occurring small non-coding RNAs of 19-25 nt as markers that can associate their specific expression profiles with cancer development are disclosed. Methods for isolating plasma fractions for the study of miRNA biomarkers and for measurement of circulating miRNA levels are disclosed.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: July 18, 2017
    Assignees: AFFYMETRIX, INC., GENISPHERE, LLC
    Inventors: Radharani Duttagupta, Keith W. Jones, Rong Jiang, Robert C. Getts, Jeremy N. Gollub
  • Circulating miRNA Biomaker Signatures
    Publication number: 20130012405
    Abstract: Methods for diagnosis and surveillance of complex multi-factorial disorders such as cancer by screening of easily accessible biomarkers are disclosed. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations in CNA levels are strong predictors of the utility of this biomarker class as clinical indicators. Methods for using microRNAs (miRNAs) representing a class of naturally occurring small non-coding RNAs of 19-25 nt as markers that can associate their specific expression profiles with cancer development are disclosed. Methods for isolating plasma fractions for the study of miRNA biomarkers and for measurement of circulating miRNA levels are disclosed.
    Type: Application
    Filed: June 18, 2012
    Publication date: January 10, 2013
    Applicants: Genisphere, LLC, AFFYMETRIX, INC.
    Inventors: Radharani Duttagupta, Keith W. Jones, Rong Jiang, Robert C. Getts, Jeremy N. Gollub