Patents by Inventor Jeremy N. Rich

Jeremy N. Rich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers for tumor initiating cells
    Patent number: 9731032
    Abstract: Aptamers consisting of a single stranded nucleic acids having 100 nucleotides or less that specifically binds to tumor initiating cancer cells are described. The aptamers can be identified by screening a large pool of randomly generated aptamers to obtain a discrete set of aptamers that specifically bind to tumor initiating cancer cells, such as those found in brain cancer or glioblastoma. The aptamers can also be linked or complexed with anticancer agents or imaging agents for use in therapy or diagnosis.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: August 15, 2017
    Assignee: The Cleveland Clinic Foundation
    Inventors: Jeremy N. Rich, Youngmi Kim, Anita B. Hjelmeland
  • APTAMERS FOR TUMOR INITIATING CELLS
    Publication number: 20170165376
    Abstract: Aptamers consisting of a single stranded nucleic acids having 100 nucleotides or less that specifically binds to tumor initiating cancer cells are described. The aptamers can be identified by screening a large pool of randomly generated aptamers to obtain a discrete set of aptamers that specifically bind to tumor initiating cancer cells, such as those found in brain cancer or glioblastoma. The aptamers can also be linked or complexed with anticancer agents or imaging agents for use in therapy or diagnosis.
    Type: Application
    Filed: February 4, 2014
    Publication date: June 15, 2017
    Inventors: Jeremy N. Rich, Youngmi Kim, Anita B. Hjelmeland
  • APTAMERS FOR TUMOR INITIATING CELLS
    Publication number: 20150366996
    Abstract: Aptamers consisting of a single stranded nucleic acids having 100 nucleotides or less that specifically binds to tumor initiating cancer cells are described. The aptamers can be identified by screening a large pool of randomly generated aptamers to obtain a discrete set of aptamers that specifically bind to tumor initiating cancer cells, such as those found in brain cancer or glioblastoma. The aptamers can also be linked or complexed with anticancer agents or imaging agents for use in therapy or diagnosis.
    Type: Application
    Filed: February 4, 2014
    Publication date: December 24, 2015
    Inventors: Jeremy N. Rich, Youngmi Kim, Anita B. Hjelmeland
  • Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells
    Publication number: 20110059114
    Abstract: Compositions and uses of gamma secretase inhibitors (GSIs) for the treatment and inhibition of gliomas in subjects in need thereof are provided. Methods for administering gamma secretase inhibitors in association with radiation for the treatment of radiation resistant gliomas are described. Compositions for the inhibition of Notch signaling and activity are provided.
    Type: Application
    Filed: August 5, 2010
    Publication date: March 10, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Bruce A. Sullenger, Jialiang Wang, Jeremy N. Rich