Patents by Inventor Jeremy Nathans

Jeremy Nathans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening and diagnostics using ATP-binding cassette transporter
    Patent number: 7189511
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: March 13, 2007
    Assignees: Baylor College of Medicine, The United States of America as represented by the Department of Health and Human Services, University of Utah Research Foundation, John Hopkins University
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Patent number: 7141420
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: November 28, 2006
    Assignees: University of Utah Research Foundation, Baylor College of Medicine, John Hopkins University, The United States of America as represented by the Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Fibroblast growth factor homologous factors (FHFs) and methods of use
    Publication number: 20040102379
    Abstract: The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
    Type: Application
    Filed: October 20, 2003
    Publication date: May 27, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Jeremy Nathans, Philip M. Smallwood
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Patent number: 6713300
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: March 30, 2004
    Assignees: University of Utah Research Foundation, Baylor College of Medicine, Johns Hopkins University, The United States of America as represented by the Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use
    Publication number: 20030220483
    Abstract: A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
    Type: Application
    Filed: January 16, 2003
    Publication date: November 27, 2003
    Applicant: THE JOHNS HOPKINS UNIVERSITY OF MEDICINE, a Maryland corporation
    Inventors: Jeremy Nathans, Philip M. Smallwood, Jennifer P. Macke
  • Fibroblast growth factor homologous factor-4
    Patent number: 6635744
    Abstract: The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
    Type: Grant
    Filed: January 25, 2000
    Date of Patent: October 21, 2003
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeremy Nathans, Philip M. Smallwood
  • Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
    Publication number: 20030170853
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 11, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Methods of screening and diagnostics using ATP-binding cassette transporter
    Publication number: 20030170852
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 11, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Fibroblast growth factor homologous factor-2 and methods of use
    Publication number: 20030166875
    Abstract: A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.
    Type: Application
    Filed: July 10, 2002
    Publication date: September 4, 2003
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Jeremy Nathans, Philip M. Smallwood, Jennifer P. Macke
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Publication number: 20030162276
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 10, 2003
    Publication date: August 28, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Wnt receptor compositions and methods
    Publication number: 20030040051
    Abstract: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
    Type: Application
    Filed: May 21, 2002
    Publication date: February 27, 2003
    Inventors: Purnima Bhanot, Marcel Brink, Cindy H. Samos, Yanshu Wang, Jen-Chih Hsieh, Deborah Andrew, Jeremy Nathans, Roeland Nusse
  • FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR-1 (FHF-1) AND METHODS OF USE
    Publication number: 20020052477
    Abstract: A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
    Type: Application
    Filed: February 16, 1999
    Publication date: May 2, 2002
    Applicant: The Johns Hopkins University School of Medicine
    Inventors: JEREMY NATHANS, PHILIP M. SMALLWOOD, JENNIFER P. MACKE
  • Fibroblast growth factor homologous factors (FHFs) and methods of use
    Patent number: 6020189
    Abstract: The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: February 1, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeremy Nathans, Philip M. Smallwood
  • Fibroblast growth factor homologous factor-2 and methods of use
    Patent number: 5876967
    Abstract: A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: March 2, 1999
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeremy Nathans, Philip M. Smallwood, Jennifer P. Macke
  • Fibroblast growth factor homologous factor-1 (FHF-1)
    Patent number: 5872226
    Abstract: A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: February 16, 1999
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeremy Nathans, Philip M. Smallwood, Jennifer P. Macke
  • Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use
    Patent number: 5693775
    Abstract: A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: December 2, 1997
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeremy Nathans, Philip M. Smallwood, Jennifer P. Macke