Patents by Inventor Jeremy Nichols
Jeremy Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240328562Abstract: A pipeline pig handling apparatus configured to provide loading and unloading of pipeline pigs and ensure a safe process thereof. The apparatus of the present invention includes a frame wherein the frame is partitioned into a first portion and a second portion. The first portion of the frame houses the drive unit wherein the drive unit includes a drive motor, a power supply, an oil reservoir, a drive ram brace unit and a ram shaft. The drive motor is operably coupled to the ram shaft and configured to provide hydraulic movement thereof. The second portion of the frame houses the plunger chamber wherein the plunger chamber further includes a plunger movably disposed therein. The plunger chamber is contiguously formed with a concentric reducer wherein the concentric reducer has a portion thereof that extends beyond an end plate of the frame and is configured with a pipe clamp.Type: ApplicationFiled: March 30, 2023Publication date: October 3, 2024Inventors: Jeremy Nichols, Jacob Joseph Tosczak
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Patent number: 11614188Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.Type: GrantFiled: November 16, 2020Date of Patent: March 28, 2023Assignee: Colder Products CompanyInventors: Todd Andrews, Jeremy Nichols, Blair Plackner, Randy Williams
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Publication number: 20210062943Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.Type: ApplicationFiled: November 16, 2020Publication date: March 4, 2021Inventors: Todd Andrews, Jeremy Nichols, Blair Plackner, Randy Williams
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Patent number: 10837581Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.Type: GrantFiled: June 29, 2017Date of Patent: November 17, 2020Assignee: Colder Products CompanyInventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
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Publication number: 20190085394Abstract: The present invention provides methods for defining a disease or condition with a wide range of etiologies based on clustering of genes belong to the same biological pathway and observed frequencies or prevalence of various patient factors assessed in a given patient population, including motor and non-motor symptoms, neuropathology, age of onset, genetics, and involvement of peripheral autonomic system, including the enteric nervous system of the gastrointestinal (GI) system. Also disclosed herein are methods and kits for early diagnosis and treatment of subjects for multisystem Lewy body disease (MLBD), including Parkinson's disease, and/or one or more GI conditions that indicate a propensity for MLBD.Type: ApplicationFiled: December 14, 2016Publication date: March 21, 2019Inventors: J. William Langston, Birgitt SCHÜLE, Linda REES, R. Jeremy NICHOLS, Carrolee BARLOW
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Publication number: 20170299099Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.Type: ApplicationFiled: June 29, 2017Publication date: October 19, 2017Inventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
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Patent number: 9726308Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.Type: GrantFiled: February 15, 2013Date of Patent: August 8, 2017Assignee: Colder Products CompanyInventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
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Publication number: 20160312194Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.Type: ApplicationFiled: July 11, 2016Publication date: October 27, 2016Inventors: Jeremy NICHOLS, Birgitt SCHÜLE
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Patent number: 9417239Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.Type: GrantFiled: September 29, 2015Date of Patent: August 16, 2016Assignee: PARKINSON'S INSTITUTEInventors: Jeremy Nichols, Birgitt Schüle
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Publication number: 20160018037Abstract: A fluid manifold includes: a main body defining a fluid pathway; and a plurality of ports coupled to the main body and in fluid communication with the fluid pathway, wherein each of the ports includes a first termination. Each first termination is configured to be coupled to a respective fluid coupler in a fluid tight manner using one or more of the following techniques: overmolding; sonic welding; spin welding; snap joints; heat welding; plastic welding; solvent bonding; vibration welding; and induction welding.Type: ApplicationFiled: July 15, 2015Publication date: January 21, 2016Inventors: Jeremy Nichols, Andrew Quick
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Publication number: 20160011196Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.Type: ApplicationFiled: September 29, 2015Publication date: January 14, 2016Inventors: Jeremy NICHOLS, Birgitt SCHÜLE
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Patent number: 9187567Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.Type: GrantFiled: May 18, 2012Date of Patent: November 17, 2015Assignee: PARKINSON'S INSTITUTEInventors: Jeremy Nichols, Birgitt Schüle
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Publication number: 20140141451Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to said novel phosphorylation sites, and laboratory and clinical uses thereof.Type: ApplicationFiled: May 18, 2012Publication date: May 22, 2014Inventors: Jeremy Nichols, Birgitt Schuelle
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Patent number: 8367349Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method may comprise or further comprise the step of assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the subcellular location of LRRK2. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.Type: GrantFiled: July 1, 2010Date of Patent: February 5, 2013Assignee: Medical Research CouncilInventors: Nicolas Dzamko, Dario Alessi, R. Jeremy Nichols
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Patent number: 8206942Abstract: A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting a compound which modulates, for example inhibits, the said LRRK2 polypeptide protein kinase activity, wherein the substrate polypeptide comprises the sequence (W/F/R/K)(W/F/R/K)(R/K)(F/W/H/R)(Y/W/R)(S/T)(L/V/I) (R/K)(R/K)(A/Y) or (W/R)(X)(X)(F/Y/H/T)(Y/W/R)(T)(X)(R/T)(R)(X), where X represents any amino acid. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. The substrate polypeptide may consist or comprise the sequence RLGWWRFYTLRRARQGNTKQ.Type: GrantFiled: September 3, 2009Date of Patent: June 26, 2012Assignee: Medical Research CouncilInventors: Dario Alessi, R. Jeremy Nichols
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Publication number: 20110256553Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.Type: ApplicationFiled: April 19, 2010Publication date: October 20, 2011Inventors: R. Jeremy Nichols, Dario Alessi, Nicolas Dzamko
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Publication number: 20110256062Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method may comprise or further comprise the step of assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the subcellular location of LRRK2. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.Type: ApplicationFiled: July 1, 2010Publication date: October 20, 2011Applicant: MEDICAL RESEARCH COUNCILInventors: Nicolas Dzamko, Dario Alessi, R. Jeremy Nichols
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Patent number: 7947468Abstract: A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radixin/moesin (ERM) family polypeptide and (2) selecting a compound which modulates the LRRK2 polypeptide protein kinase activity. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. A catalytically active fragment of LRRK2 is identified, requiring the GTPase, COR and kinase domains as well as the WD_40-like motif and C-terminal tail.Type: GrantFiled: October 2, 2008Date of Patent: May 24, 2011Assignee: Medical Research CouncilInventors: Dario Alessi, R. Jeremy Nichols
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Publication number: 20100068742Abstract: A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting a compound which modulates, for example inhibits, the said LRRK2 polypeptide protein kinase activity, wherein the substrate polypeptide comprises the sequence (W/F/R/K)(W/F/R/K)(R/K)(F/W/H/R)(Y/W/R)(S/T)(L/V/I) (R/K)(R/K)(A/Y) or (W/R)(X)(X)(F/Y/H/T)(Y/W/R)(T)(X)(R/T)(R)(X), where X represents any amino acid. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. The substrate polypeptide may consist or comprise the sequence RLGWWRFYTLRRARQGNTKQ.Type: ApplicationFiled: September 3, 2009Publication date: March 18, 2010Inventors: Dario Alessi, R. Jeremy Nichols
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Publication number: 20100019487Abstract: A female coupling includes a body defining a fluid pathway therethrough, and a slot extending transversely with respect to the fluid pathway, and a latch positioned in the slot to move between locked and unlocked positions. One or both of the body and the latch are molded of a material including a reduced friction additive.Type: ApplicationFiled: July 24, 2009Publication date: January 28, 2010Inventors: Charles Peter deCler, Jeremy Nichols