Patents by Inventor Jeremy Nichols

Jeremy Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240328562
    Abstract: A pipeline pig handling apparatus configured to provide loading and unloading of pipeline pigs and ensure a safe process thereof. The apparatus of the present invention includes a frame wherein the frame is partitioned into a first portion and a second portion. The first portion of the frame houses the drive unit wherein the drive unit includes a drive motor, a power supply, an oil reservoir, a drive ram brace unit and a ram shaft. The drive motor is operably coupled to the ram shaft and configured to provide hydraulic movement thereof. The second portion of the frame houses the plunger chamber wherein the plunger chamber further includes a plunger movably disposed therein. The plunger chamber is contiguously formed with a concentric reducer wherein the concentric reducer has a portion thereof that extends beyond an end plate of the frame and is configured with a pipe clamp.
    Type: Application
    Filed: March 30, 2023
    Publication date: October 3, 2024
    Inventors: Jeremy Nichols, Jacob Joseph Tosczak
  • Patent number: 11614188
    Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: March 28, 2023
    Assignee: Colder Products Company
    Inventors: Todd Andrews, Jeremy Nichols, Blair Plackner, Randy Williams
  • Publication number: 20210062943
    Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 4, 2021
    Inventors: Todd Andrews, Jeremy Nichols, Blair Plackner, Randy Williams
  • Patent number: 10837581
    Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 17, 2020
    Assignee: Colder Products Company
    Inventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
  • Publication number: 20190085394
    Abstract: The present invention provides methods for defining a disease or condition with a wide range of etiologies based on clustering of genes belong to the same biological pathway and observed frequencies or prevalence of various patient factors assessed in a given patient population, including motor and non-motor symptoms, neuropathology, age of onset, genetics, and involvement of peripheral autonomic system, including the enteric nervous system of the gastrointestinal (GI) system. Also disclosed herein are methods and kits for early diagnosis and treatment of subjects for multisystem Lewy body disease (MLBD), including Parkinson's disease, and/or one or more GI conditions that indicate a propensity for MLBD.
    Type: Application
    Filed: December 14, 2016
    Publication date: March 21, 2019
    Inventors: J. William Langston, Birgitt SCHÜLE, Linda REES, R. Jeremy NICHOLS, Carrolee BARLOW
  • Publication number: 20170299099
    Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.
    Type: Application
    Filed: June 29, 2017
    Publication date: October 19, 2017
    Inventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
  • Patent number: 9726308
    Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: August 8, 2017
    Assignee: Colder Products Company
    Inventors: Randy Williams, Blair Plackner, Todd Andrews, Jeremy Nichols
  • Publication number: 20160312194
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Application
    Filed: July 11, 2016
    Publication date: October 27, 2016
    Inventors: Jeremy NICHOLS, Birgitt SCHÜLE
  • Patent number: 9417239
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 16, 2016
    Assignee: PARKINSON'S INSTITUTE
    Inventors: Jeremy Nichols, Birgitt Schüle
  • Publication number: 20160018037
    Abstract: A fluid manifold includes: a main body defining a fluid pathway; and a plurality of ports coupled to the main body and in fluid communication with the fluid pathway, wherein each of the ports includes a first termination. Each first termination is configured to be coupled to a respective fluid coupler in a fluid tight manner using one or more of the following techniques: overmolding; sonic welding; spin welding; snap joints; heat welding; plastic welding; solvent bonding; vibration welding; and induction welding.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Jeremy Nichols, Andrew Quick
  • Publication number: 20160011196
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Application
    Filed: September 29, 2015
    Publication date: January 14, 2016
    Inventors: Jeremy NICHOLS, Birgitt SCHÜLE
  • Patent number: 9187567
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: November 17, 2015
    Assignee: PARKINSON'S INSTITUTE
    Inventors: Jeremy Nichols, Birgitt Schüle
  • Publication number: 20140141451
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to said novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Application
    Filed: May 18, 2012
    Publication date: May 22, 2014
    Inventors: Jeremy Nichols, Birgitt Schuelle
  • Patent number: 8367349
    Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method may comprise or further comprise the step of assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the subcellular location of LRRK2. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: February 5, 2013
    Assignee: Medical Research Council
    Inventors: Nicolas Dzamko, Dario Alessi, R. Jeremy Nichols
  • Patent number: 8206942
    Abstract: A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting a compound which modulates, for example inhibits, the said LRRK2 polypeptide protein kinase activity, wherein the substrate polypeptide comprises the sequence (W/F/R/K)(W/F/R/K)(R/K)(F/W/H/R)(Y/W/R)(S/T)(L/V/I) (R/K)(R/K)(A/Y) or (W/R)(X)(X)(F/Y/H/T)(Y/W/R)(T)(X)(R/T)(R)(X), where X represents any amino acid. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. The substrate polypeptide may consist or comprise the sequence RLGWWRFYTLRRARQGNTKQ.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: June 26, 2012
    Assignee: Medical Research Council
    Inventors: Dario Alessi, R. Jeremy Nichols
  • Publication number: 20110256553
    Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.
    Type: Application
    Filed: April 19, 2010
    Publication date: October 20, 2011
    Inventors: R. Jeremy Nichols, Dario Alessi, Nicolas Dzamko
  • Publication number: 20110256062
    Abstract: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method may comprise or further comprise the step of assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the subcellular location of LRRK2. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 20, 2011
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Nicolas Dzamko, Dario Alessi, R. Jeremy Nichols
  • Patent number: 7947468
    Abstract: A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radixin/moesin (ERM) family polypeptide and (2) selecting a compound which modulates the LRRK2 polypeptide protein kinase activity. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. A catalytically active fragment of LRRK2 is identified, requiring the GTPase, COR and kinase domains as well as the WD_40-like motif and C-terminal tail.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: May 24, 2011
    Assignee: Medical Research Council
    Inventors: Dario Alessi, R. Jeremy Nichols
  • Publication number: 20100068742
    Abstract: A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting a compound which modulates, for example inhibits, the said LRRK2 polypeptide protein kinase activity, wherein the substrate polypeptide comprises the sequence (W/F/R/K)(W/F/R/K)(R/K)(F/W/H/R)(Y/W/R)(S/T)(L/V/I) (R/K)(R/K)(A/Y) or (W/R)(X)(X)(F/Y/H/T)(Y/W/R)(T)(X)(R/T)(R)(X), where X represents any amino acid. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. The substrate polypeptide may consist or comprise the sequence RLGWWRFYTLRRARQGNTKQ.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 18, 2010
    Inventors: Dario Alessi, R. Jeremy Nichols
  • Publication number: 20100019487
    Abstract: A female coupling includes a body defining a fluid pathway therethrough, and a slot extending transversely with respect to the fluid pathway, and a latch positioned in the slot to move between locked and unlocked positions. One or both of the body and the latch are molded of a material including a reduced friction additive.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 28, 2010
    Inventors: Charles Peter deCler, Jeremy Nichols