Abstract: A blower collar for use with a blower and a burner. The blower collar includes: a bottom portion having a circular opening surrounded by a burner mounting rim configured to be mounted to the burner; an upper portion having a non-circular opening surrounded by a blower mounting rim and being configured to mount to the blower; and a central portion between the bottom portion and the upper portion, the central portion having a surrounding wall connected to the burner mounting rim and the blower mounting rim, the surrounding wall surrounding an inner pass through having a cross-sectional shape that changes from the non-circular opening of the upper portion to the circular opening of the bottom portion.

Abstract: An electrochemical cell that oxidizes a solution provides a continuous and stable supply of an oxidizing ion solution to a fixture or vessel used for the purposes of decontaminating metal and metal alloys. The electrochemical cell includes an anode compartment that oxidizes the solution in nitric acid or methane sulfonic acid at a rate equal to or greater than a rate of reduction, or generates the oxidizing ions prior to use in a batch. The electrochemical cell is part of a larger system that facilitates online measurement system which measures the oxidizing ion solution and the dissolved PuO2, UO2, AmO2, other radionuclides, or other contaminates in real-time. Solution decontamination system removes the dissolved PuO2/UO2/AmO2, other radionuclides, or other contaminates from the oxidizing ion solution, real time acoustic monitoring of the thickness of the surface being contaminated, and automation of a delivery system facilitates flow between surface and electrochemical cell.

Abstract: An apparatus and method for inspecting an object by optical triangulation, where the signal of interest in a captured image corresponds to an interaction between a light beam and an environment surrounding the object rather than between a light beam and the object itself. The surrounding environment may be configured to interact in a manner that is detectable by filling it with a flowable scattering medium, e.g. a gas, mist or vapour comprising a suspension of fine particles in air. Light that is scattered by the flowable scattering medium is visible in a captured image. Where the flowable scattering medium is not present, e.g. because the object blocks it, the scattered signal is less. A boundary of a scattered signal region may thus provide information about the location of an object.

Abstract: Devices, systems, and methods are provided for enhanced geographical caching of estimated arrival times. A method may include receiving respective user inputs indicative of respective users being in transit to a destination location from within a geographic region; determining, for the first user and the second user, a first estimated time of arrival from a first geographical area to the destination location, the first geographical area including the first location and the second location; identifying a third location of the first device at a third time, wherein the third location is within the first geographical area; determining that a time-to-live (TTL) of the first estimated time of arrival has not expired at the third time; and refraining from recalculating the first estimated time of arrival.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is provided. The device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material. The device further includes an adjustment mechanism to allow a user to adjust a dimension of the chamber to allow the chamber to accommodate, one at a time, each of a plurality of consumables having different sizes.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material included in a consumable, the non-combustible aerosol provision device having: a receptacle for receiving the consumable; and an adaptor configured to adapt the non-combustible aerosol provision device by varying an effective length of the receptacle such that each of a plurality consumables of different lengths, which are individually receivable in the receptacle, when received in the receptacle for use, protrude from the non-combustible aerosol provision device by substantially equal amounts.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, Table VIII, or Table IX. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.

Abstract: A mix manifold (16) includes a plurality of valves to control the flow of material therethrough. First and second valves (36a, 36b) are linked for simultaneous actuation. The first and second valves each include valve members (56a, 56b) disposed within and rotatable relative to seal bodies (58a, 58b). The valve members seal against the seal bodies and the seal bodies seal against the manifold. A solvent valve (36c) also includes a valve member (56c) in a seal body (58c). The first and second valves are configured to open only when the solvent valve is closed. The solvent valve is configured to open only when the first and second valves are closed. The solvent valve can rotate between a plurality of positions to control the flow of solvent to flowpaths downstream of the first and second valves.

Abstract: A target illuminating stapling device for safely fastening an item to a substrate includes a staple gun and a bulb. The staple gun comprises a staple driver, a handle, and a staple cartridge. The staple driver is positioned in a front portion of the staple gun. The handle is hingedly engaged to the front portion and extends over a back portion of the staple gun. The handle is operationally engaged to the staple driver. Levering of the handle actuates the staple driver to fasten a staple into a substrate. An item that is positioned between the staple and the substrate is fastened to the substrate. The staple cartridge selectively feeds the staple to the staple driver. The bulb is engaged to the staple gun proximate to the staple driver. The bulb selectively illuminates a target area of the substrate into which the staple is to be fastened.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, Table VIII, or Table IX. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values being joined smoothly with one another to form a complete airfoil shape.

Abstract: A stator vane includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, or Table VIII. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.

Abstract: A medication delivery device with a sensing system to determine at least one of a dose set and a dose delivery. The sensing system is operable to detect relative rotational positions of first and second members of the device which are indicative of at least one of an amount of a dose set and an amount of a dose delivered by operation of the device, and generate outputs correlated to such relative rotational positions. The system includes a wiper coupled to the first member, and a sensing band coupled to the second member for physically contacting the wiper as the second member rotates relative to the first member. A controller electrically communicates with the sensing system to determine, based on the generated outputs of the sensing system, at least one of the amount of the dose set and the amount of the dose delivered by operation of the device.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in Table I. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, or Table IV. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.