Abstract: The present disclosure involves a composition and method of treatment of glioblastoma, using ZIKA virus.

Abstract: Disclosed herein, inter alia, are methods of making and using engineered T cells useful for expressing a chimeric antigen receptor (CAR) targeted to a cell surface protein (e.g., a CAR targeted to IL13R?2, which is highly expressed on glioblastoma cells).

Abstract: Methods and compositions for increasing tumor cell sensitivity to natural killer cell-mediated toxicity by inhibiting CHMP2A or other endosomal sorting complex required for transport in the tumor cell.

Abstract: The present disclosure involves a composition and method of treatment of glioblastoma, using ZIKA virus.

Abstract: Computer systems and methods for managing the investigation of potentially fraudulent payment card transactions are provided. The computer system includes a memory device for storing data and a processor in communication with the memory device. The computer system is programmed to receive an authorization request message associated with at least one transaction initiated with a payment card. The computer system transmits a scoring request message associated with the at least one transaction to a fraud scoring system. The computer system receives a fraud scoring response associated with the at least one transaction from the fraud scoring system. The fraud scoring response includes a first instruction directing a change to a status of the payment card. The computer system transmits a status change message to a cardholder management system.

Abstract: A method of treating glioblastoma multiforme (GBM) in a subject in need thereof including administering to the subject a therapeutically effective amount of an Eg5 inhibitor.

Abstract: Computer systems and methods for managing the investigation of potentially fraudulent payment card transactions are provided. The computer system includes a memory device for storing data and a processor in communication with the memory device. The computer system is programmed to receive an authorization request message associated with at least one transaction initiated with a payment card. The computer system transmits a scoring request message associated with the at least one transaction to a fraud scoring system. The computer system receives a fraud scoring response associated with the at least one transaction from the fraud scoring system. The fraud scoring response includes a first instruction directing a change to a status of the payment card. The computer system transmits a status change message to a cardholder management system.

Abstract: Computer systems and methods for managing the investigation of potentially fraudulent payment card transactions are provided. The computer system includes a memory device for storing data and a processor in communication with the memory device. The computer system is programmed to retrieve a case representing at least one transaction initiated with a payment card and designated as potentially fraudulent, provide the case to a contact management system, retrieve cardholder card and contact information for the actual cardholder associated with the payment card used in the at least one transaction, and provide the cardholder card and contact information to the contact management system, wherein the contact management system is configured to initiate an investigation into the case based on the cardholder card and contact information.