Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: The present application relates to methods for the isolation of EVs from a sample containing EVs, the method comprising: (i) contacting the sample with one or more polyethylenimines to form an EV-polyethylenimine complex; and (ii) separating the EV-polyethylenimine complex from the sample. Also included in the application are kits for performing the methods for isolating EVs and methods of diagnosis and therapy using the EVs isolated using the described methods.

Abstract: A dynamic video communications system provides real time provisioning of a video communication session in a domain video network between a set of user devices. The real time provisioning is implemented by receiving an identifier of a video communication session from a user device, where the identifier includes a domain and a name, determining an authentication principle associated with the user device, where the authentication principle includes a domain of the user, checking whether the domain of the user matches a domain of the video communication session, and joining the user device with the video communication session.

Abstract: A method and apparatus are provided that are implemented at a conference apparatus to provide an optimization of video conferencing resource utilization. The method receives a plurality of resource constraints where each resource constraint is from a conference device in a plurality of conference devices, wherein at least a first resource constraint of a first conference device contains an indication of a video processing capability of the first conference device. The method further computes a conference solution matrix for the plurality of conference devices based on the plurality of resource constraints, wherein the conference solution matrix contains a solution entry for each of the plurality of conference devices, and wherein for the first conference device, a corresponding first solution entry indicates a video processing solution selection for the first conference device. Solution entries are then sent to corresponding conference devices of the plurality of conference devices.

Abstract: A method of proximity-based conference session transfer is disclosed. The method is implemented at a conference device and it starts with the conference device generating a conference session code based on an encrypted conference session message received from a conference server. The conference device communicates the conference session code to an area in proximity to the conference device, where a user device in the area in proximity to the conference device receives the conference session code and requests the conference server to coordinate the conference device to assume a conference session of the user device. The conference device then receives a message from the conference server requesting the conference device to assume the conference session of the user device, and it assumes the conference session of the user device by performing conference functions according to input from the user device.

Abstract: A dynamic video communications system provides real time provisioning of a video communication session in a domain video network between a set of user devices. The real time provisioning is implemented by receiving an identifier of a video communication session from a user device, where the identifier includes a domain and a name, determining an authentication principle associated with the user device, where the authentication principle includes a domain of the user, checking whether the domain of the user matches a domain of the video communication session, and joining the user device with the video communication session.

Abstract: A system is provided which enables the computer- and web-assisted assimilation of fixed income securities data. The system uses this data to identify potential trading opportunities. Semi-structured and unstructured data describing fixed income holdings, indications of interest and axes are automatically interpreted and assimilated into the system. Instances of similar data across different sets of data are automatically identified and subsequently notify individuals uniquely. Bids and offers are routed to the correct individuals after comparison with assimilated data.