Abstract: A microfluidic dispensing system may include multiple supply lines for simultaneous filling of diaphragm pumps associated with each supply line. Each supply line may fill corresponding groups of diaphragm pumps with a corresponding ingredient to a supply reservoir for the supply line. Accordingly, different groups of diaphragm pumps corresponding to different supply lines may be filled with corresponding ingredients simultaneously. Those ingredients corresponding to the different groups of diaphragm pumps may also be dispensed simultaneously, giving rise to a faster and more efficient fluidic dispensing system.

Abstract: A metering assembly includes a fluidic chip and metering chambers. Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters. Purge channels communicate with the metering chambers and controlled purge valves allow reverse flow wash fluid to wash the metering chamber. Pressure ports are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) to selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids.

Abstract: A microfluidic dispensing system may include diaphragm pumps that may be used for aspirating in corresponding ingredients via a nozzle or a tip from supply sources. Tips may be placed in contact with ingredient supply sources, and through repeated actuation of the diaphragm pumps, desired volumes of ingredients are aspirated into the tips. In some cases, an air plug is aspirated into the tips before an ingredient. Once the desired volume of each ingredient is reached within each tip, the ingredients are dispensed from the tips through repeated actuation of corresponding diaphragm pumps.

Abstract: A metering assembly includes a fluidic chip and metering chambers. Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters. Purge channels communicate with the metering chambers and controlled purge valves allow reverse flow wash fluid to wash the metering chamber. Pressure ports are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids.

Abstract: A metering assembly includes a fluidic chip and metering chambers. Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters. Purge channels communicate with the metering chambers and controlled purge valves allow reverse flow wash fluid to wash the metering chamber. Pressure ports are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) to selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids.

Abstract: A method and apparatus for providing information to a plurality of users based on the relevancy of the information to the users are disclosed. An incoming message is received. Similarity scores are generated indicating similarities of the incoming message to features of a plurality of messages. Relevancy scores are generated for the plurality of users, the relevancy scores indicating relevancies of the incoming message to the plurality of users based on the similarity scores and a plurality of user profiles including information descriptive of the plurality of users' preferences for the features of the plurality of users. Message information derived from the incoming message, the relevancy scores, and the plurality of user profiles is delivered to at least some of the plurality of users.

Abstract: A microfluidic dispensing system may include multiple supply lines for simultaneous filling of diaphragm pumps associated with each supply line. Each supply line may fill corresponding groups of diaphragm pumps with a corresponding ingredient to a supply reservoir for the supply line. Accordingly, different groups of diaphragm pumps corresponding to different supply lines may be filled with corresponding ingredients simultaneously. Those ingredients corresponding to the different groups of diaphragm pumps may also be dispensed simultaneously, giving rise to a faster and more efficient fluidic dispensing system.

Abstract: A microfluidic dispensing system may include diaphragm pumps that may be used for aspirating in corresponding ingredients via a nozzle or a tip from supply sources. Tips may be placed in contact with ingredient supply sources, and through repeated actuation of the diaphragm pumps, desired volumes of ingredients are aspirated into the tips. In some cases, an air plug is aspirated into the tips before an ingredient. Once the desired volume of each ingredient is reached within each tip, the ingredients are dispensed from the tips through repeated actuation of corresponding diaphragm pumps.

Abstract: A metering assembly includes a fluidic chip and metering chambers. Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters. Purge channels communicate with the metering chambers and controlled purge valves allow reverse flow wash fluid to wash the metering chamber. Pressure ports are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids.

Abstract: A metering assembly includes a fluidic chip and metering chambers. Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters. Purge channels communicate with the metering chambers and controlled purge valves allow reverse flow wash fluid to wash the metering chamber. Pressure ports are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids.

Abstract: A method and apparatus for providing information to a plurality of users based on the relevancy of the information to the users are disclosed. An incoming message is received. Similarity scores are generated indicating similarities of the incoming message to features of a plurality of messages. Relevancy scores are generated for the plurality of users, the relevancy scores indicating relevancies of the incoming message to the plurality of users based on the similarity scores and a plurality of user profiles including information descriptive of the plurality of users' preferences for the features of the plurality of users. Message information derived from the incoming message, the relevancy scores, and the plurality of user profiles is delivered to at least some of the plurality of users.

Abstract: A method and apparatus for providing information to a plurality of users based on the relevancy of the information to the users are disclosed. An incoming message is received. Similarity scores are generated indicating similarities of the incoming message to features of a plurality of messages. Relevancy scores are generated for the plurality of users, the relevancy scores indicating relevancies of the incoming message to the plurality of users based on the similarity scores and a plurality of user profiles including information descriptive of the plurality of users' preferences for the features of the plurality of users. Message information derived from the incoming message, the relevancy scores, and the plurality of user profiles is delivered to at least some of the plurality of users.

Abstract: A method and apparatus for providing information to a plurality of users based on the relevancy of the information to the users are disclosed. An incoming message is received. Similarity scores are generated indicating similarities of the incoming message to features of a plurality of messages. Relevancy scores are generated for the plurality of users, the relevancy scores indicating relevancies of the incoming message to the plurality of users based on the similarity scores and a plurality of user profiles including information descriptive of the plurality of users' preferences for the features of the plurality of users. Message information derived from the incoming message, the relevancy scores, and the plurality of user profiles is delivered to at least some of the plurality of users.

Abstract: Method and apparatus for regulating a flow of information to one or more users is disclosed. A system includes a relevancy threshold for a user and an incoming message having a relevancy score, the relevancy score indicating a relevancy of the incoming message to the user. A method for regulating a flow of information to a user of the system is disclosed. The method determines whether the relevancy score of the incoming message satisfies the relevancy threshold, and delivers to the user message information derived from the incoming message and adjusting the relevancy threshold when the relevancy score of the incoming message satisfies the relevancy threshold. The method adjusts the relevancy threshold by an amount determined by a time-dependent function when the relevancy score of the incoming message does not satisfy the relevancy threshold.