Abstract: An enclosure or plenum that supports a looped pump tube is hingedly connected to a framed thin-walled heat exchange bag through which working fluid from an intravascular heat exchange catheter flows. The frame with bag can be inserted between cold plates to exchange heat with the working fluid flowing through the bag. With the framed bag between the plates, the looped pump tube from the enclosure or plenum is receivable in the raceway of a peristaltic pump, which pumps working fluid through the system.

Abstract: A heat exchange assembly can be removably engaged between two cold plates of a heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad. The heat exchange assembly may have a serpentine, winding, tortuous, or sinuous configuration, or it may have one or more curves, turns and/or bends and/or can have a flattened transverse cross-section to facilitate heat exchange with the cold plates.

Abstract: Cold plates through which refrigerant flows define a slot between them that can receive a cassette through which sterile working fluid with a relatively low flow rate flows from an intravascular beat exchange catheter or external pad. The slot may have bulge cavities along the edges to permit the membrane of the cassette to expand and thus establish fluid supply and return passageways.

Abstract: A peristaltic pump has an arcuate raceway with a partially concave inner surface extending through an arc of at least one hundred eighty degrees (180°). The arc defines a midpoint, and a rotor faces the inner surface of the raceway and is both rotatable relative to the raceway and translationally movable relative to the raceway between a pump position, wherein the rotor is spaced from the midpoint a first distance, and a tube load position, wherein the rotor is spaced from the midpoint a second distance greater than the first distance. A motor is coupled to the rotor to rotate the rotor plural are rollers arranged on the rotor to contact tubing disposed between the rotor and the raceway when the rotor is in the pump position. The motor is prevented from stopping at a predetermined angular position to facilitate loading and unloading tubing.

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes along the sides of which are disposed inlet and outlet tubes. Working fluid from the catheter is directed from the inlet tube between the membranes to the outlet tube. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes in tension. Working fluid from the catheter is directed between the membranes. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract: A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad includes a working fluid that circulates between the catheter or pad and a fluid cassette, and a refrigerant system that flows against the outer sides of cold plates between which the cassette is disposed.

Abstract: A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad includes a working fluid that circulates between the catheter or pad and a fluid cassette, and a refrigerant system that flows against the outer sides of cold plates between which the cassette is disposed. An outer wall of the system is transparent so that a person can view the refrigerant as it circulates, ensuring proper operation.

Abstract: Cold plates through which refrigerant flows define a slot between them that can receive a cassette through which sterile working fluid with a relatively low flow rate flows from an intravascular heat exchange catheter. The working fluid from the catheter is heated or cooled by heat exchange with the cold plates through the walls of the cassette to maintain the sterility of the working fluid. On the other hand, high flow rate working fluid chambers surround the cold plates and non-sterile working fluid from an external heat exchange pad flows through the high flow rate working fluid chambers to exchange heat through direct contact with the cold plates.