Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: A vehicle route guidance computer system is configured to store habitual travel routes for drivers; detect driving by a vehicle of one of the drivers along one of the habitual travel routes; monitor vehicle location along the route; monitor traffic signal states and traffic conditions along the route; calculate an optimal velocity of the vehicle to maximize likelihood of reaching a next traffic signal along the route when the signal is green, and transmit a guidance signal to a guidance device in a vehicle to advise the driver to decelerate or accelerate the vehicle. The vehicle route guidance computer system may be further configured to detect an adverse condition along the route, calculate an alternative route, and transmit a direction guidance signal to the guidance device for guiding the driver to the alternative route.

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P) receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.

Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Abstract: A vehicle route guidance computer system is configured to store habitual travel routes for drivers; detect driving by a vehicle of one of the drivers along one of the habitual travel routes; monitor vehicle location along the route; monitor traffic signal states and traffic conditions along the route; calculate an optimal velocity of the vehicle to maximize likelihood of reaching a next traffic signal along the route when the signal is green, and transmit a guidance signal to a guidance device in a vehicle to advise the driver to decelerate or accelerate the vehicle. The vehicle route guidance computer system may be further configured to detect an adverse condition along the route, calculate an alternative route, and transmit a direction guidance signal to the guidance device for guiding the driver to the alternative route.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: In a computerized system, a route-based analysis may be performed relating to a commuting route for a customer of an insurance company. The insurance company may provide information to the customer based on the result of the analysis. The information may relate to an insurance policy premium quotation, or to suggested vehicle deceleration or acceleration to improve driving efficiency and/or safety.

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Abstract: The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.