Patents by Inventor Jerod Ptacin

Jerod Ptacin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNO ONCOLOGY COMBINATION THERAPY WITH IL-2 CONJUGATES AND ANTI-EGFR ANTIBODIES
    Publication number: 20260115295
    Abstract: Disclosed herein are methods for treating a cancer in a subject in need thereof, comprising administering IL-2 conjugates in combination with an anti-EGFR antibody.
    Type: Application
    Filed: August 20, 2025
    Publication date: April 30, 2026
    Applicant: Synthorx, Inc.
    Inventors: Giovanni ABBADESSA, Carolina E. CAFFARO, Joseph LEVEQUE, Marcos MILLA, Jerod PTACIN, Timothy R. WAGENAAR
  • IL-2 conjugates and methods of use thereof
    Patent number: 12521437
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: January 13, 2026
    Assignee: SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • Interleukin 10 conjugates and uses thereof
    Patent number: 12491254
    Abstract: Disclosed herein are interleukin 10 conjugates and uses in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the IL-10 conjugates.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: December 9, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Carolina E. Caffaro, Jerod Ptacin, Marcos Milla
  • CROSSLINKING MULTISPECIFIC ANTIBODIES
    Publication number: 20250353926
    Abstract: Provided herein are compositions and methods for cross-linking multi-specific antibodies to targets with conjugates. Further provided herein are conjugates comprising targeting domains, wherein the targeting domain comprises an unnatural amino acid. Further provided herein are methods of treating disease with cross-linking multi-specific antibodies.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 20, 2025
    Inventors: Sergio DURON, Jason ROLAND, Jerod PTACIN, Analeah HEIDT, Jun LIU, Yorke ZHANG
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
    Publication number: 20250325632
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: January 16, 2025
    Publication date: October 23, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20250325633
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: July 2, 2025
    Publication date: October 23, 2025
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Marcos MILLA, Jerod PTACIN
  • HEAD AND NECK CANCER COMBINATION THERAPY COMPRISING AN IL-2 CONJUGATE AND PEMBROLIZUMAB
    Publication number: 20250302950
    Abstract: Disclosed herein are methods for treating classic Hodgkin lymphoma (cHL) in a subject in need thereof, comprising administering an IL-2 conjugate in combination with an anti-PD-1 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: December 20, 2022
    Publication date: October 2, 2025
    Inventors: Giovanni Abbadessa, Paula Fraenkel, Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
    Publication number: 20250270535
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: May 2, 2025
    Publication date: August 28, 2025
    Applicants: Synthorx, Inc., The Scripps Research Institute
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
  • Cytokine conjugates for the treatment of autoimmune diseases
    Patent number: 12377131
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: August 5, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Carolina E. Caffaro, Marcos Milla, Jerod Ptacin
  • IL-15 conjugates and uses thereof
    Patent number: 12344648
    Abstract: Disclosed herein are interleukin (IL)-15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates. In some embodiments, at least one amino acid residue in the IL-15 conjugate is replaced by the structure of Formula (I) described herein.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: July 1, 2025
    Assignee: Synthrox, Inc.
    Inventors: Carolina E. Caffaro, Jerod Ptacin, Marcos Milla
  • Incorporation of unnatural nucleotides and methods thereof
    Patent number: 12319944
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Grant
    Filed: October 4, 2023
    Date of Patent: June 3, 2025
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina Caffaro, Hans Aerni, Yorke Zhang, Emil C. Fischer, Aaron W. Feldman, Vivian T. Dien, Floyd E. Romesberg
  • Cytokine conjugates for the treatment of proliferative and infectious diseases
    Patent number: 12318431
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: June 3, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • IL-2 Conjugates and Methods of Use to Treat Autoimmune Diseases
    Publication number: 20250154218
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: September 16, 2024
    Publication date: May 15, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
  • INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
    Publication number: 20250084410
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: November 21, 2024
    Publication date: March 13, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Denis A. MALYSHEV, Carolina E. CAFFARO
  • Il-2 conjugates and methods of use to treat autoimmune diseases
    Patent number: 12234271
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: February 25, 2025
    Assignee: Synthorx, Inc.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • IL-15 Conjugates and Uses Thereof
    Publication number: 20240383957
    Abstract: Disclosed herein are interleukin (IL)-15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates. In some embodiments, at least one amino acid residue in the IL-15 conjugate is replaced by the structure of Formula (I) described herein.
    Type: Application
    Filed: January 26, 2024
    Publication date: November 21, 2024
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Jerod PTACIN, Marcos MILLA
  • IL-15 Conjugates and Uses Thereof
    Publication number: 20240287151
    Abstract: Disclosed herein are interleukin (IL) 15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 29, 2024
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Jerod PTACIN, Marcos MILLA
  • HEAD AND NECK CANCER COMBINATION THERAPY COMPRISING AN IL-2 CONJUGATE AND PEMBROLIZUMAB
    Publication number: 20240245792
    Abstract: Disclosed herein are methods for treating head and neck squamous cell carcinoma (HNSCC) in a subject in need thereof, comprising administering IL-2 conjugates in combination with one or more additional agents.
    Type: Application
    Filed: November 30, 2023
    Publication date: July 25, 2024
    Inventors: Giovanni Abbadessa, Carolina E. Caffaro, Brigitte Demers, Joseph Leveque, Wan-Ju Meng, Marcos Milla, Jerod Ptacin
  • HEAD AND NECK CANCER COMBINATION THERAPY COMPRISING AN IL-2 CONJUGATE AND CETUXIMAB
    Publication number: 20240226309
    Abstract: Disclosed herein are methods for treating head and neck squamous cell carcinoma (HNSCC) in a subject in need thereof, comprising administering IL-2 conjugates in combination with cetuximab.
    Type: Application
    Filed: November 30, 2023
    Publication date: July 11, 2024
    Applicant: Synthorx, Inc.
    Inventors: Giovanni ABBADESSA, Carolina E. CAFFARO, Brigitte DEMERS, Joseph LEVEQUE, Wan-Ju MENG, Marcos MILLA, Jerod PTACIN
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
    Publication number: 20240082359
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: June 1, 2023
    Publication date: March 14, 2024
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA