Patents by Inventor Jeroen Hans Nieuwenhuis

Jeroen Hans Nieuwenhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240053334
    Abstract: Methods and systems are provided for compensating for gravitational effects on a sensor system. In one example, a sensor system includes a sample container configured to receive a sample containing an analyte to be tested, the sample container comprising a detection surface and a plurality of signal generating elements in the sample container, wherein the detection surface comprises a binding surface, which has been partially functionalized with capture elements that can bind, directly and/or indirectly, the analyte and/or the signal generating elements, wherein the signal generating elements have a spatial distribution profile over the detection surface, wherein the spatial distribution profile has a gradient along a first axis, and wherein the binding surface has an axis of symmetry that is orthogonal to the first axis.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 15, 2024
    Applicant: Siemens Healthineers Nederland B.V.
    Inventors: Alexander van Reenen, Jeroen Hans Nieuwenhuis
  • Patent number: 11519923
    Abstract: A system (1) for detecting an analyte of interest in a sample is disclosed that comprises a measurement chamber (21) for metering the sample and including a defined concentration of an activator (27) causing the generation of a product when interacting with the analyte of interest, a heating element (31) thermally coupled to the measurement chamber, a controller (33) adapted to control the heating element such that the measurement chamber is maintained at a defined temperature (Td), a sensor (35) adapted to detect said product, a timer (37) adapted to time an interaction time between the sample and the activator; and a processor (39) responsive to the sensor and the timer.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: December 6, 2022
    Assignee: Siemens Healthineers Nederland B.V.
    Inventors: Jeroen Hans Nieuwenhuis, Markus Hendrikus Van Roosmalen, Per Venge
  • Patent number: 11270782
    Abstract: The present invention relates to the means and methods for the detection of bacterial infections, methods discriminating between viral and bacterial infections, methods of stratifying patients for subsequent treatment and further diagnostic purposes and methods to monitor antibiotherapy. The present invention is based on the detection of specific epitopes of human neutrophil lipocalin (HNL) using specific binding agents.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: March 8, 2022
    Assignee: Koninklijke Philips N.V.
    Inventors: Markus Hendrikus Van Roosmalen, Veronique Semjonow, Jeroen Hans Nieuwenhuis, Per Venge
  • Patent number: 11125744
    Abstract: The present invention relates to a device (100) for detecting an analyte (12) in a body fluid sample (14) containing a plurality of cells (16). The device (100) comprises a sample input (18) for receiving a body fluid sample (14) containing a plurality of cells (16), and an immunoassay unit (20) comprising a detection surface (28) for performing an immunoassay of said body fluid sample (14) containing a plurality of cells (16). The immunoassay unit (20) comprises an activating reagent (22) for activating the plurality of cells (16) contained in the body fluid sample (14) to release an analyte (12), an anti-analyte-antibody (24) capable of binding to said analyte (12) to form a complex (26) comprising said anti-analyte-antibody (24) and said analyte (12), wherein the forming of said complex (26) proceeds at least partially simultaneous to the activating of said plurality of cells (16).
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: September 21, 2021
    Assignee: SIEMENS HEALTHINEERS NEDERLAND B.V.
    Inventors: Markus Hendrikus Van Roosmalen, Jeroen Hans Nieuwenhuis, Per Venge
  • Patent number: 10895571
    Abstract: Methods for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample by applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte and block the at least one epitope from binding to a detection particle. The detection of the multi-epitope target analyte may further include the use of a second capture entity, which can specifically bind to the same or a similar epitope of the multi-epitope target analyte as the first capture entity. The multi-epitope target may be detected through the use of a system comprising a sensor surface and the use of a first capture entity to block the at least one epitope from binding to a detection particle.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: January 19, 2021
    Assignee: SIEMENS HEALTHINEERS NEDERLAND B.V.
    Inventors: Toon Hendrik Evers, Menno Willem Jose Prins, Jeroen Hans Nieuwenhuis
  • Patent number: 10466163
    Abstract: During an assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest (ROI) may be rejected.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: November 5, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Derk Jan Wilfred Klunder, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 10307759
    Abstract: The invention relates to a method and a biosensor system (300) for the detection of target components (TC) in a biological sample. In a preferred embodiment, magnetic purification particles (PP) are added to the sample that can bind interfering components (IC) (if present) which interfere with the detection process. The purification particles (PP) with bound interfering components (IC) may be removed from the sample and transferred through a magneto-capillary valve (MCV1) into a waste chamber (320).
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: June 4, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Gwenola Sabatte, Wilhelmina Maria Hardeman
  • Patent number: 10133978
    Abstract: A device such as a disposable cartridge has an RFID tag (30) having an antenna (10), and a fluidic element (20, 160), the antenna having a shape to at least partly enclose an area, at least a part of the fluidic element being located in this area. By having such a structure, the device can be made more compact or the antenna can be made larger, and hence the costs for a given performance can be reduced, or the storage space for a given number of devices can be reduced.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: November 20, 2018
    Assignee: Minicare B.V.
    Inventors: Bernardus Jozef Maria Beerling, Petrus Johannes Wilhelmus Van Lankvelt, Wendela Meertens, Jeroen Hans Nieuwenhuis
  • Patent number: 10006907
    Abstract: A cartridge for detection of target components in a liquid sample includes a sample chamber, at least two reservoirs that can be furnished with magnetic particles, and at least two corresponding sensitive zones in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: June 26, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Mara Johanna Jacoba Sijbers, Petrus Johannes Wilhelmus Van Lankvelt, Femke Karina De Theije, Jeroen Hans Nieuwenhuis
  • Patent number: 9841421
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 9696246
    Abstract: A sensor system (100) includes a reader (150) with a sensor unit (155, 156) and an accommodation Space (151) for an exchangeable cartridge (110). The cartridge (110) is held in the accommodation space (151) by at least one contact element (111) which has an increased thermal resistance and/or a contact area of reduced size. Thus a more homogenous temperature distribution can be achieved within the cartridge (110), reducing distortions which might adversely affect optical measurements.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 4, 2017
    Assignee: KONINKLIJKE PHLIPS N.V.
    Inventors: Bernardus Jozef Maria Beerling, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt, Wendela Meertens, Patrick Zuidema
  • Patent number: 9575081
    Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogues.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: February 21, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jeroen Hans Nieuwenhuis, Ahmed Mohammed Taki Jehanli, Femke Karina De Theije, Eduard Gerard Marie Pelssers
  • Patent number: 9557328
    Abstract: A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40?).
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: January 31, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Femke Karina De Theije, Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt
  • Publication number: 20160291004
    Abstract: A cartridge for detection of target components in a liquid sample includes a sample chamber, at least two reservoirs that can be furnished with magnetic particles, and at least two corresponding sensitive zones in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 6, 2016
    Inventors: Mara Johanna Jacoba Sijbers, Petrus Johannes Wilhelmus Van Lankvelt, Femke Karina De Theije, Jeroen Hans Nieuwenhuis
  • Patent number: 9103843
    Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogs.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: August 11, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Jeroen Hans Nieuwenhuis, Ahmed Mohammed Taki Jehanli, Femke Karina De Theije, Eduard Gerard Marie Pelssers
  • Patent number: 8970215
    Abstract: A sensor device for sensing particles of a sample, the sensor device including a sensing unit adapted for sensing a detection signal indicative of the presence of the particles, a viscosity measurement unit adapted for measuring the viscosity of the sample, and a correction unit adapted for correcting the detection signal based on the measured viscosity.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: March 3, 2015
    Assignee: Koninklijkle Philips N.V.
    Inventors: Jeroen Hans Nieuwenhuis, Godefridus Johannes Verhoeckx, Menno Willem Jose Prins, Petrus Johannes Wilhelmus Van Lankvelt, Kim Van Ommering
  • Patent number: 8770049
    Abstract: A device, system and method for sampling sample material for an analyte including a receiving swab, wherein at least a portion of the receiving swab is compressible; a sensor for sensing the analyte; and a casing, wherein the casing at least partially encloses the receiving swab and the sensor and allows for a transfer of sample material received by the receiving swab to the sensor along a transfer path inside of the casing. The compressible portion of the receiving swab is located inside the casing, wherein by compressing the compressible portion, the transfer path is closable towards the outside of the device.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: July 8, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Eduard Gerard Marie Pelssers, Jeroen Hans Nieuwenhuis
  • Publication number: 20140057366
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Application
    Filed: November 28, 2011
    Publication date: February 27, 2014
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus dionisius Van Zon
  • Publication number: 20140051187
    Abstract: The invention relates to a method and a sensor device (100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest(ROI) may be rejected.
    Type: Application
    Filed: April 23, 2012
    Publication date: February 20, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Derk Jan Wilfred Klunder, Jeroen Hans Nieuwenhuis, Joannes Baptist Adianus Dionisius Van Zon
  • Publication number: 20140041462
    Abstract: The invention relates to a sensor system (100) comprising a reader (150) with a sensor unit (155, 156) and an accommodation Space (151) for an exchangeable cartridge (110). The cartridge (110) is held in said accommodation space (151) by at least one contact element (111) which has an increased thermal resistance and/or a contact area of reduced size. Thus a more homogenous temperature distribution can be achieved within the cartridge (110), reducing distortions which might adversely affect optical measurements.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 13, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Bernardus Jozef Maria Beerling, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt, Wendela Meertens, Patrick Zuidema