Patents by Inventor Jeroen Lammertyn

Jeroen Lammertyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10807093
    Abstract: The present invention relates to a fluid conduit system and manufacture thereof, for the propulsion of fluids. The micro- or millifluidic system is useful within LOC, POC diagnostics digital ELISA, drug delivery applications or sampling. The system includes a capillary pump and a fluid conduit operationally connected to the pump, and a gas-permeable liquid-sealed unit with a vent hole gas-permeable to the outside. The fluid conduit includes a first conduit zone prefilled or pre-Tillable with a first volume of trigger liquid, upstream of the unit with the vent hole, a third conduit zone with a further volume, upstream of the capillary pump, and a second conduit zone pre-filled or pre-Tillable with a working liquid between the first and third conduit zones, connected to both, and directly connected to the first conduit zone. The first volume is proportionally larger than or equal to the volume of the third conduit zone.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 20, 2020
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Jaroslav Belotserkovsky, Francesco Dal Dosso, Tadej Kokalj, Jeroen Lammertyn
  • Publication number: 20200290009
    Abstract: A miniaturized, automated method for controlled printing of large arrays of nano- to femtoliter droplets by actively transporting mother droplets over hydrophilic-in-hydrophobic (“HIH”) micropatches. The technology uses single or double-plate devices where mother droplets can be actuated and HIH micropatches on one or both plates of the device where the droplets are printed. Due to the selective wettability of the hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over the arrays. The parent droplets are moved by various droplet actuation principles. Also, a method using two plates placed one top another while being separated by a spacer. One plate is dedicated to confirming and guiding parent droplets by using hydrophilic patches in a hydrophobic matrix, while the other plate contains HIH arrays for printing of the droplets.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventors: Jeroen Lammertyn, Daan Witters
  • Patent number: 10695737
    Abstract: A novel miniaturized and highly automated method for the controlled printing of large arrays of nano- to femtoliter droplets is presented by actively transporting mother droplets over hydrophilic-in-hydrophobic micropatches. The proposed technology consists of single plate or double-plate devices where mother droplets can be actuated and hydrophilic-in-hydrophobic micropatches on one or both plates of the device where nano- to femtoliter droplets are printed. Due to the selective wettability of the more wettable hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over these arrays. The parent droplets can be moved by different droplet actuation principles, for example, by using the principle of electrowetting-on-dielectric droplet actuation. We propose another method that uses two plates that are placed on top of each other while being separated by a spacer.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: June 30, 2020
    Assignee: Katholieke Universiteit Leuven, K.U.Leuven R&D
    Inventors: Jeroen Lammertyn, Daan Witters
  • Publication number: 20200001300
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Application
    Filed: May 23, 2019
    Publication date: January 2, 2020
    Inventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
  • Patent number: 10421990
    Abstract: A method and kits are provided for nucleic acid quantification and discrimination using surface plasmon resonance (SPR). The method provided is able to significantly enhance the detection limit and multiplex the discrimination assay using the melting properties of the target DNA on top of standard PCR reaction. By using the heating and cooling cycles of the polymerase chain reaction (PCR) or Ligation chain reaction (LCR), DNA is melted and hybridized onto the SPR sensor surface together with a nanoparticle label. Thus, during every cycle of DNA amplification, the quantity and type of target DNA can be monitored.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: September 24, 2019
    Assignee: FOX BIOSYSTEMS NV
    Inventors: Jeroen Lammertyn, Karel Knez, Filip Delport
  • Patent number: 10335791
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: July 2, 2019
    Assignees: Abbott Laboratories, The Katholieke Universiteit Leuven
    Inventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
  • Publication number: 20180345288
    Abstract: The present invention relates to a fluid conduit system and manufacture thereof, for the propulsion of fluids. The micro- or millifluidic system is useful within LOC, POC diagnostics digital ELISA, drug delivery applications or sampling. The system includes a capillary pump and a fluid conduit operationally connected to the pump, and a gas-permeable liquid-sealed unit with a vent hole gas-permeable to the outside. The fluid conduit includes a first conduit zone prefilled or pre-Tillable with a first volume of trigger liquid, upstream of the unit with the vent hole, a third conduit zone with a further volume, upstream of the capillary pump, and a second conduit zone pre-filled or pre-Tillable with a working liquid between the first and third conduit zones, connected to both, and directly connected to the first conduit zone. The first volume is proportionally larger than or equal to the volume of the third conduit zone.
    Type: Application
    Filed: August 6, 2018
    Publication date: December 6, 2018
    Inventors: Jaroslav BELOTSERKOVSKY, Francesco DAL DOSSO, Tadej KOKALJ, Jeroen LAMMERTYN
  • Publication number: 20180207640
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Application
    Filed: January 17, 2018
    Publication date: July 26, 2018
    Inventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
  • Publication number: 20180015437
    Abstract: A novel miniaturized and highly automated method for the controlled printing of large arrays of nano- to femtoliter droplets is presented by actively transporting mother droplets over hydrophilic-in-hydrophobic micropatches. The proposed technology consists of single plate or double-plate devices where mother droplets can be actuated and hydrophilic-in-hydrophobic micropatches on one or both plates of the device where nano- to femtoliter droplets are printed. Due to the selective wettability of the more wettable hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over these arrays. The parent droplets can be moved by different droplet actuation principles, for example, by using the principle of electrowetting-on-dielectric droplet actuation. We propose another method that uses two plates that are placed on top of each other while being separated by a spacer.
    Type: Application
    Filed: July 7, 2017
    Publication date: January 18, 2018
    Applicant: Katholieke Universiteit Leuven, K.U.Leuven R&D
    Inventors: Jeroen Lammertyn, Daan Witters
  • Publication number: 20160298178
    Abstract: A method and kits are provided for nucleic acid quantification and discrimination using surface plasmon resonance (SPR). The method provided is able to significantly enhance the detection limit and multiplex the discrimination assay using the melting properties of the target DNA on top of standard PCR reaction. By using the heating and cooling cycles of the polymerase chain reaction (PCR) or Ligation chain reaction (LCR), DNA is melted and hybridized onto the SPR sensor surface together with a nanoparticle label. Thus, during every cycle of DNA amplification, the quantity and type of target DNA can be monitored.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 13, 2016
    Inventors: Jeroen LAMMERTYN, Karel KNEZ, Filip DELPORT
  • Publication number: 20140378339
    Abstract: A novel miniaturized and highly automated method for the controlled printing of large arrays of nano- to femtoliter droplets is presented by actively transporting mother droplets over hydrophilic-in-hydrophobic micropatches. The proposed technology consists of single plate or double-plate devices where mother droplets can be actuated and hydrophilic-in-hydrophobic micropatches on one or both plates of the device where nano- to femtoliter droplets are printed. Due to the selective wettability of the more wettable hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over these arrays. The parent droplets can be moved by different droplet actuation principles, for example, by using the principle of electrowetting-on-dielectric droplet actuation. We propose another method that uses two plates that are placed on top of each other while being separated by a spacer.
    Type: Application
    Filed: January 24, 2013
    Publication date: December 25, 2014
    Applicant: KATHOLIEKE UNIVERSITEIT EUVEN
    Inventors: Jeroen Lammertyn, Daan Witters