Patents by Inventor Jeroen Mattijs Bezemer
Jeroen Mattijs Bezemer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8163307Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.Type: GrantFiled: November 25, 2009Date of Patent: April 24, 2012Assignee: Biolex Therapeutics, Inc.Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
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Patent number: 7867518Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.Type: GrantFiled: May 15, 2009Date of Patent: January 11, 2011Assignee: Biolex Therapeutics, Inc.Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
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Patent number: 7736674Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.Type: GrantFiled: July 6, 2007Date of Patent: June 15, 2010Assignee: Biolex Therapeutics, Inc.Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
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Publication number: 20100074868Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.Type: ApplicationFiled: November 25, 2009Publication date: March 25, 2010Applicant: BIOLEX THERAPEUTICS, INC.Inventors: Anne Chantal BECHET, Riemke VAN DIJKHUIZEN-RADERSMA, Martin STIGTER, Jeroen Mattijs BEZEMER
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Publication number: 20090226532Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.Type: ApplicationFiled: May 15, 2009Publication date: September 10, 2009Applicant: BIOLEX THERAPEUTICS, INC.Inventors: Anne Chantal BECHET, Riemke VAN DIJKHUIZEN-RADERSMA, Martin STIGTER, Jeroen Mattijs BEZEMER
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Patent number: 7226612Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.Type: GrantFiled: September 25, 2003Date of Patent: June 5, 2007Assignee: Chienna B.V.Inventors: Jerome Sohier, Jeroen Mattijs Bezemer
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Patent number: 6835391Abstract: The invention relates to new biologically degradable aliphatic copolymers of the polyesteramide or polyesterurethane type. The invention further relates to a method for preparing the copolymers and to products which can be manufactured from the new copolymers.Type: GrantFiled: March 29, 2002Date of Patent: December 28, 2004Assignee: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Jan Feijen, Pieter Jelle Dijkstra
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Publication number: 20040086544Abstract: The invention relates to a process for loading a polymer with one or more bioactive agents, using a wet spinning technique. The invention further relates to a polymer loaded with one or more bioactive agents, obtainable by said process and to the use thereof as a carrier for controlled drug release or as scaffold for tissue engineering.Type: ApplicationFiled: October 28, 2003Publication date: May 6, 2004Applicant: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
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Patent number: 6730721Abstract: The invention relates to a process for molding a copolymer of a polyalkylene glycol terephthalate and an aromatic ester, comprising the steps of: a) preparing a solution of the copolymer in a suitable first solvent; and b) forming a gel of the solution.Type: GrantFiled: January 15, 2002Date of Patent: May 4, 2004Assignee: IsoTis N.V.Inventors: Jeroen Mattijs Bezemer, Joost Robert de Wijn, Jan Nieuwenhuis
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Patent number: 6685957Abstract: A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of amphiphilic block copolymer containing hydrophilic blocks such as polyalkylene glycol and hydrophobic blocks such as an aromatic ester dissolved in a first solvent immiscible with water to form an emulsion. The emulsion is injected through a nozzle into a second solvent miscible with the first solvent in which the copolymer is essentially insoluble to form a solid copolymer fiber loaded with the bioactive agent. The fiber is shaped into an implant. Water content of the aqueous solution of bioactive agent affects rate of release of the bioactive agent in vivo. Bioactive agents include peptides, oligopeptides, polypeptides and proteins. The implant may be used as a carrier for controlled drug release or as a scaffold for tissue engineering.Type: GrantFiled: September 29, 2000Date of Patent: February 3, 2004Assignee: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
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Publication number: 20030050422Abstract: The invention relates to new biologically degradable aliphatic copolymers of the polyesteramide or polyesterurethane type. The invention further relates to a method for preparing the copolymers and to products which can be manufactured from the new copolymers.Type: ApplicationFiled: March 29, 2002Publication date: March 13, 2003Applicant: IsoTis N.V.Inventors: Jeroen Mattijs Bezemer, Jan Feijen, Pieter Jelle Dijkstra
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Patent number: 6500193Abstract: The invention relates to a suture comprising a copolymer of a polyethylene glycol terephtalate and a polybutylene terephtalate, which copolymer comprises 45-60 wt. %, based on the weight of the copolymer, of the polyethylene glycol terephtalate, and 55-40 wt. %, based on the weight of the copolymer, of the polybutylene terephtalate.Type: GrantFiled: July 12, 2000Date of Patent: December 31, 2002Assignee: IsoTis N.V.Inventors: Jeroen Mattijs Bezemer, Joost Robert de Wijn, Jan Nieuwenhuis
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Publication number: 20020161371Abstract: The invention relates to a fixative device for bone tissue, which device comprises a copolymer of a polyalkylene glycol and an aromatic polyester.Type: ApplicationFiled: February 1, 2002Publication date: October 31, 2002Applicant: Iso Tis N.V.Inventors: Jeroen Mattijs Bezemer, Joost Robert De Wijn, Jan Nieuwenhuis, Paul Carel Hubertus De Joode, Clements Antoni Van Blitterswijk
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Publication number: 20020128378Abstract: The invention relates to a process for molding a copolymer of a polyalkylene glycol terephthalate and an aromatic ester, comprising the steps of: a) preparing a solution of the copolymer in a suitable first solvent; and b) forming a gel of the solution.Type: ApplicationFiled: January 15, 2002Publication date: September 12, 2002Applicant: IsoTis N.V.Inventors: Jeroen Mattijs Bezemer, Joost Robert de Wijn, Jan Nieuwenhuis