Patents by Inventor Jerome Anthony Iacobelli

Jerome Anthony Iacobelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D3 analogs
    Patent number: 6452028
    Abstract: A compound of the formula wherein R is hydrogen or hydroxy, each R1 is ethyl, propyl, butyl, isopropyl or t-butyl, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—. These compounds are useful for the treatment of hyperproliferative disorders, skin diseases, and sebaceous gland diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: September 17, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Vitamin D3 analogs
    Patent number: 6329538
    Abstract: A compound of the formula wherein R is hydrogen or hydroxy, each R2 is independently H or halogen, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—, provided that when A is —CH2—CH2—, R2 is H.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: December 11, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • 16-ene-26,27-bishomo cholecalciferols
    Patent number: 6030963
    Abstract: The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R.sup.1 is hydrogen or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatment of neoplastic diseases, such as leukemia.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: February 29, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Vitamin D.sub.3 analogs
    Patent number: 5939408
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R.sub.2 is lower alkyl or C(R.sub.3).sub.3 and R.sub.3 is halogen, X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2, and A is --C.tbd.C-- ##STR2## or --CH.sub.2 --CH.sub.2 --, which are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, and sebaceous gland diseases.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: August 17, 1999
    Assignee: Hoffman-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol
    Patent number: 5840718
    Abstract: The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R.sup.1 is H.sub.2 or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2 and (b) an inert carrier.Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases, such as psoriasis, neoplastic diseases, such as leukemia, and sebaceous gland diseases, such as acne and sebhorreic dermatitis.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: November 24, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Process for the preparation of 1.alpha.,25-dihydroxycholecalciferol
    Patent number: 3993675
    Abstract: A novel process for the preparation of 1.alpha.,25-dihydroxycholecalciferol and intermediates thereof is disclosed.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Milan Radoje Uskokovic, Thomas Albert Narwid, Jerome Anthony Iacobelli, Enrico Baggiolini