Patent number: 9546159
Abstract: The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n?1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C?O)NR2, CH?NR, (C?S)OR, (C?O)SR, CS2R, SO2R, SO2NR2, SO3R, P(O)(OR)2, P(O)(R)2, B(OR)2 group where R is a (C1-C6) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and R1 and R2 each represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C1-C6) alkyl, phenyl or phenyl-(C1-C6)-alkyl group, in which R1 and R2 form, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C1-C6) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same.
Type:
Grant
Filed:
October 14, 2013
Date of Patent:
January 17, 2017
Assignee:
Centre National de la Recherche Scientifique (CNRS)
Inventors:
Pascal Collin, Maxim Egorov, Bernard Delpech, Joanna Bakala, Maria Achab, Jérome Bignon, Odile Thoison, Michel Benechie
Publication number: 20150344460
Abstract: The present invention relates to a compound of formula (I) in which: —m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n?1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C?O)NR2, CH?NR, (C?S)OR, (C?O)SR, CS2R, SO2R, SO2NR2, SO3R, P(O)(OR)2, P(O)(R)2, B(OR)2 group where R is a (C1-C6) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and R1 and R2 each represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C1-C6) alkyl, phenyl or phenyl-(C1-C6)-alkyl group, in which R1 and R2 form, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C1-C6) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same.
Type:
Application
Filed:
October 14, 2013
Publication date:
December 3, 2015
Inventors:
Pascal Collin, Maxim Egorov, Bernard Delpech, Joanna Bakala, Maria Achab, Jérome Bignon, Odile Thoison, Michel Benechie
Patent number: 7405309
Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.
Type:
Grant
Filed:
January 14, 2005
Date of Patent:
July 29, 2008
Assignee:
Centre National de la Recherche Scientifique (CNRS)
Inventors:
Joanna Bakala, Denyse Herlem, Emile Benechie, Jérôme Bignon, Françoise Khuong-Huu, Guy Jean Marie Potier, legal representative, Marie-Claude Denise Michèle Zelveyan, legal representative, Catherine Marie Germaine Magnan, legal representative, Odette Drion, legal representative, Pierre Potier
Patent number: 7235532
Abstract: The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benef
Type:
Grant
Filed:
September 20, 2001
Date of Patent:
June 26, 2007
Assignee:
Centre National de la Recherche Scientfique
Inventors:
Joanna Bakala, Jean-Paul Pierre Potier, Françoise Lawrence, Nathalie Cheviron, Jérôme Bignon, Yves Fromes