Abstract: A system and method for operating a touchscreen of a gas-enhanced electrosurgical generator. The generator has a display module and a primary controller. The display module has a plurality of touch sensors, a PCB power relay and a CPU. The method comprises selecting electrosurgery settings through a graphical user interface, activating through an input device plasma delivery from the gas-enhanced electrosurgical generator, disabling the plurality of touch sensors through software running on the primary controller, disconnecting power from the plurality of touch sensors with the PCB power relay in response to the disabling of the plurality of touch sensors, applying power to an electrode in the plasma accessory connected to the gas-enhanced electrosurgical generator, and de-activating through an input device plasma delivery from the gas-enhanced electrosurgical generator to the plasma accessory connected to the gas-enhanced electrosurgical generator.

Abstract: A system and method for voice control of operating room electrical equipment. The system comprises an electrosurgical generator having a controller with a memory, a graphical user interface controlled by said controller, a power module, a field programmable gate array, and a voice recognition module connected to said field programmable gate array, a data storage connected to said controller in said electrosurgical generator; and electrical operating room equipment connected to said voice recognition module, wherein said electrical operating room equipment is configured to receive and decrypt encrypted commands from said voice recognition module. The audio input to the voice recognition system may be a microphone chip in a electrosurgical accessory.

Abstract: A system and method for using a concomitant effect of cold atmospheric plasma and Trastuzumab to overcome Trastuzumab invalidity or resistance and enhances the outcome of breast cancer therapy in both HER2-positive and negative cancer cells.

Abstract: A configurable electrosurgical generator front panel. The configurable electrosurgical generator front panel has a front panel frame, a display screen or tablet computing device, and a plurality of connectors for connecting accessories to the front panel frame. The front panel in the front panel assembly provides a novel structure for inserting a screen or tablet device into the front panel frame and securing it in place.

Abstract: A method for bioengineering exosomes for cancer treatment. The method comprises the steps of isolating target tumor cells from a tissue sample, culturing the isolated target tumor cells, treating the cultured target tumor cells with cold atmospheric plasma to release exosomes from the target tumor cells, and collecting the released exosomes. The step of culturing the target tumor cells may comprise seeding the isolated target tumor cells in wells and incubating the target tumor cells in a culture media, for example, for 24 hours. The culture media may comprise Dulbecco's Modified Eagle Medium, an antibiotic and 10% fetal bovine serum. The step of culturing the target tumor cells may further comprise replacing the culture media with Dulbecco's Modified Eagle Medium and an antibiotic. The target tumor cells may comprise, for example, one of U87 cells, KKU-055 cells and triple negative MDA-MB-231 cells.

Abstract: A method for a method for treatment of cholangiocarcinoma (CCA) with cold atmospheric plasma and Folfirinox. The method includes treating a patient having CCA with a low dosage FOLFIRINOX regimen, for example, 6.73 nM, giving the patient the low-dosage FOLFIRINOX regimen pre-operatively, surgically removing the cancerous tumor from the patient, continuing the low-dosage FOLFIRINOX treatment regimen intra-operatively, applying cold atmospheric plasma to the surgical margins surrounding the area in the patient from which the tumor was removed, and continuing the FOLFIRINOX post-operatively.

Abstract: A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of treating a patient with a pharmaceutical for suppressing apolipoprotein E genes, selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with the computing device, settings data associated with the selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with the computing device, the retrieved settings data to a cold atmospheric plasma system.

Abstract: A method for inducing cell death in breast cancer regardless of subtyping through histone mRNA oxidation and degradation during the early S-phase of the cell cycle. A method for monitoring levels of oxidized histone mRNA in breast cancer cells, comprising the steps of isolating histone mRNA from breast cancer cells, incubating the histone mRNA with a peptide according to SEQ ID NO: 1 and determining the levels of oxidized histone mRNA by measuring the fluorescence intensity.

Abstract: An automated robotic navigational surgical system that will detect dye (which is injected external to this system) that marks the areas of operation. The color and type of dye used will be one that is both distinct and highly reflective. There are four sections to the automated robotic navigational surgical system: Energy Source, Display Unit and Control Arm, Sensor Array, Disposable Tip.

Abstract: A system for adaptive control of non-thermal plasma treatment on a patient. The system has a electrosurgical generator, having a power module, a memory, a first current sensor configured to sense an electrical current on the active electrode, a second current sensor configured to sense a current on the return electrode, a voltage sensor configured to sense a voltage difference between the active electrode and the return electrode, and a feedback control module, wherein the control module is configured to automatically adjusts a power output of the electrosurgical generator based on outputs of the first current sensor, the second current sensor and the voltage sensor to maintain an electrical current on the active electrode within a range to provide non-thermal plasma.

Abstract: A robotic medical surgical system docking connector. The docking connector has a housing, a plurality of controllers in the housing, a plurality of electrical interfaces in the housing, an interface for connecting the housing to a robotic surgical arm; and a mechanical interface for connecting the housing to a robotic surgical end effector. The housing has first and second handles, a programmable push button on at least one of the first and second handles; and a plurality of cable connectors. The plurality of electrical interfaces may comprise, a digital input output interface, an analog input output interface, a CANopen interface, a USB (5V,GND, Sig1,2) interface; and a programmable MCU interface.

Abstract: A method for treating cancer. The method comprises treating a patient having a cancerous tumor with the gene inhibitor CPI203 pre-operatively to inhibit upregulation of a particular gene, surgically removing the cancerous tumor, treating the patient with the gene inhibitor intra-operatively to inhibit upregulation of a particular gene, applying cold atmospheric plasma to surgical margins around the area in the patient from which the tumor was surgically removed, and treating the patient with the gene inhibitor CPI203 post-operatively.

Abstract: An electrosurgical method and device for simultaneously cutting and coagulating tissue with an electrosurgical device having an electrode and a channel wherein said channel has a port near a proximal end of said electrode, wherein the method comprises the steps of causing an inert gas to flow through said channel and exit said port, applying high-frequency energy to said electrode while said inert gas flows through said channel, wherein said high-frequency energy applied to said electrode continuously plasmatizes inert gas exiting said port, initiating an electrical discharge from said electrode through said continuously plasmatized inert gas to said tissue, cutting tissue with said electrode, maintaining said electrical discharge from said electrode through said plasmatized inert gas while cutting tissue with said electrode to cause coagulation of said tissue simultaneously with said cutting.

Abstract: A method to oxidize pan-cancer epitopes of COL6A3 protein (peptide sequences 1. FLLDGSANV (SEQ ID NO: 1), 2. FLLDGSEGV (SEQ ID NO: 2) and 3. FLLDGSINF (SEQ ID NO: 3)) by cold atmospheric plasma treatment for developing solid tumor cancer vaccines.

Abstract: A method for applying cold atmospheric plasma treatment on target tissue. The method comprises the steps of selecting through a graphical user interface on a display a particular cancer cell line associated with the target tissue, retrieving in response to the selecting, with a computing device connected to the display, settings data from a database of cell line data and associated settings data in a storage, applying, with the computing device, the retrieved settings data to a cold atmospheric plasma system, and treating cancer tissue with cold atmospheric plasma at the retrieved settings. The method may further comprise displaying the retrieved settings on a display.

Abstract: A method for inducing cell death in breast cancer regardless of subtyping through histone mRNA oxidation and degradation during the early S-phase of the cell cycle. A method for monitoring levels of oxidized histone mRNA in breast cancer cells, comprising the steps of isolating histone mRNA from breast cancer cells, incubating the histone mRNA with a peptide according to SEQ ID NO: 1 and determining the levels of oxidized histone mRNA by measuring the fluorescence intensity.

Abstract: A method for treating cancer. The method comprises treating a patient having a cancerous tumor with a gene inhibitor pre-operatively to inhibit upregulation of a particular gene, surgically removing the cancerous tumor, treating the patient with the gene inhibitor intra-operatively to inhibit upregulation of a particular gene, applying cold atmospheric plasma to surgical margins around the area in the patient from which the tumor was surgically removed, and treating the patient with the gene inhibitor post-operatively.

Abstract: A system and method in accordance with the present invention controls the dosage of cold plasma generated multi-species delivered to a patient, the distance of the CAP probe should keep constant around 1.5-2.5 mm as well as the treating time and treating area should be controlled during the procedure. The robotic system will have a quick attachable connection to the CAP probe and the robotic system will keep the constant distance from CAP tip's end to patient body, at same time provide surface scan with computer planned controllable surface treatment area, treating time and step distance between two return scans.

Abstract: A system and method for voice control of operating room electrical equipment. The system comprises an electrosurgical generator a controller with a memory, a graphical user interface controlled by said controller, a power module, a field programmable gate array, and a voice recognition module connected to said field programmable gate array, a data storage connected to said controller in said electrosurgical generator; and electrical operating room equipment connected to said voice recognition module, wherein said electrical operating room equipment is configured to receive and decrypt encrypted commands from said voice recognition module. The electrical operating room equipment may said electrosurgical generator or a robotic surgical system or other electrical equipment in an operating room. The connection between said electrical operating room equipment and said voice recognition module may be wireless.

Abstract: A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with said computing device, settings data associated with said selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with said computing device, said retrieved settings data to a cold atmospheric plasma system.