Abstract: Disclosed is a method for capturing target cells or molecules in solution, comprising steps of: (I) getting medium containing said target cells or molecules into an apparatus comprising a capturing device for capturing said target cells or molecules; (II) getting said medium flow through said capturing device; (III) removing unbound debris, cells and molecules; (IV) getting said target cells or molecules detached from the capturing device; and (V) collecting said target cells or molecules; wherein said capturing device comprises at least one functionalized mesh comprising a mesh substrate and a functional layer formed on said mesh substrate, wherein said functional layer comprises capturing substances that can specifically bind with said target cells or molecules. The method has high specificity, as well as high throughput, and is suitable for capturing cells or molecules in a solution or expressed at the surface of cell membranes. It is particularly suited to capture and sort circulating tumor cells.

Abstract: A sensor device for detecting a target species in an aqueous media and/or measuring the concentration of a target species in an aqueous media, the sensor device comprising: (a) an active semiconductor comprising an organic semiconductor material that exhibit substantially the same transfer curve for a period of at least 24 hours when first exposed to air; and (b) a structure for directing an aqueous media into contact with the sensor device.

Abstract: Disclosed are a functionalized mesh and fluidic apparatus for capturing cells or molecules in solution. The functionalized mesh comprises a mesh substrate and a functional layer formed on said mesh substrate, wherein the functional layer comprises capturing substances that can specifically bind with the target cells or molecules. The mesh and apparatus of the invention have high specificity, as well as high throughput, and are suitable for capturing molecules in solution or expressed at the surface of cell membranes. It is particularly suited to capture and sort circulating tumor cells.

Abstract: Disclosed is a method for capturing target cells or molecules in solution, comprising steps of: (I) getting medium containing said target cells or molecules into an apparatus comprising a capturing device for capturing said target cells or molecules; (II) getting said medium flow through said capturing device; (III) removing unbound debris, cells and molecules; (IV) getting said target cells or molecules detached from the capturing device; and (V) collecting said target cells or molecules; wherein said capturing device comprises at least one functionalized mesh comprising a mesh substrate and a functional layer formed on said mesh substrate, wherein said functional layer comprises capturing substances that can specifically bind with said target cells or molecules. The method has high specificity, as well as high throughput, and is suitable for capturing cells or molecules in a solution or expressed at the surface of cell membranes. It is particularly suited to capture and sort circulating tumor cells.

Abstract: A sensor device for detecting a target species in an aqueous media and/or measuring the concentration of a target species in an aqueous media, the sensor device comprising: (a) an active semiconductor comprising an organic semiconductor material that exhibit substantially the same transfer curve for a period of at least 24 hours when first exposed to air; and (b) a structure for directing an aqueous media into contact with the sensor device.

Abstract: An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied at least in part by vapor deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets of layers, wherein each set has at least one layer formed by dissociation of a polymeric precursor and then deposition of that precursor, and another layer is a biocompatible liquid.

Abstract: An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied at least in part by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets of layers, wherein each set has at least one layer formed by dissociation of a polymeric precursor and then deposition of that precursor, and another layer is a biocompatible liquid.