Patents by Inventor Jerome Cluzeau

Jerome Cluzeau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of beta-aminosulfone compounds
    Patent number: 9944599
    Abstract: The present invention relates to processes for preparing ?-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of sulfone group containing isoindoline-based compounds, in particular apremilast.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: April 17, 2018
    Inventors: Gaj Stavber, Jerome Cluzeau
  • Processes For The Preparation Of Beta-Aminosulfone Compounds
    Publication number: 20170174627
    Abstract: The present invention relates to processes for preparing ?-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of sulfone group containing isoindoline-based compounds, in particular apremilast.
    Type: Application
    Filed: May 27, 2015
    Publication date: June 22, 2017
    Applicant: Lek Pharmaceuticals d.d.
    Inventors: Gaj Stavber, Jerome Cluzeau
  • Catalyzed carbonylation in the synthesis of angiotensin II antagonists
    Patent number: 8445693
    Abstract: One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3?-(2?-halo-biphenyl-4-ylmethyl)-1,7?-dimethyl-2?-propyl-1H,3?H-[2,5?]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: May 21, 2013
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Zdenko Casar, Anton Copar, Jerome Cluzeau, Andrej Premrl
  • ((2,4)-4,6-dihydroxytetrahydro-2-pyran-2-yl)methyl carboxylate and process for the production thereof
    Patent number: 8404870
    Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: March 26, 2013
    Assignee: LEK Pharmaceuticals D.D.
    Inventors: Jerome Cluzeau, Zdenko Casar, Peter Mrak, Matej Oslaj, Gregor Kopitar
  • SYNTHESIS OF 1-(2,3-DIHYDROBENZOFURAN-4-YL)ETHANONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON
    Publication number: 20120083526
    Abstract: The present invention relates in general to the field of organic chemistry and in particular to the preparation of 1-(2,3-dihydrobenzofuran-4-yl)ethanone, an intermediate in preparation of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon.
    Type: Application
    Filed: April 6, 2010
    Publication date: April 5, 2012
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventor: Jerome CLuzeau
  • SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE
    Publication number: 20120071673
    Abstract: The present invention relates in general to the field of organic chemistry and in particular to the preparation of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon, and analogues thereof.
    Type: Application
    Filed: February 11, 2010
    Publication date: March 22, 2012
    Applicant: LEK Pharmaceuticals D.D.
    Inventor: Jerome Cluzeau
  • SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5, 4-B] FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF REMELTEON
    Publication number: 20110184058
    Abstract: The present invention describes the preparation of 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one, a key intermediate in preparation of ramelteon. The present invention also describes further preceding intermediate compounds useful for the synthesis of 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one.
    Type: Application
    Filed: July 13, 2009
    Publication date: July 28, 2011
    Applicant: Lek Pharmaceuticals D.D.
    Inventor: Jerome Cluzeau
  • CATALYZED CARBONYLATION IN THE SYNTHESIS OF ANGIOTENSIN II ANTAGONISTS
    Publication number: 20110098329
    Abstract: One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3?-(2?-halo-biphenyl-4-ylmethyl)-1,7?-dimethyl-2?-propyl-1H,3?H-[2,5?]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.
    Type: Application
    Filed: March 19, 2009
    Publication date: April 28, 2011
    Applicant: LEK Pharmaceuticals D.D.
    Inventors: Zdenko Casar, Anton Copar, Jerome Cluzeau, Andrej Premrl
  • ((2S,4R)-4,6-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL)METHYL CARBOXYLATE AND PROCESS FOR THE PRODUCTION THEREOF
    Publication number: 20110046375
    Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.
    Type: Application
    Filed: January 20, 2009
    Publication date: February 24, 2011
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Jerome Cluzeau, Zdenko Casar, Peter Mrak, Matej Oslaj, Gregor Kopitar
  • Method for reducing sludge of a biological ozone treatment system
    Patent number: 7335304
    Abstract: Methods for treating aqueous effluent, which include reducing sludge formation during the biological treatment of an aqueous effluent. The sludge formation is reduced by injecting an ozone containing gas into an aeration tank which contains the effluent. The affluent is in contact with microorganisms in the tank at least once during the method. The ozone containing gas contains at least 2.5 mg of ozone per liter of the gas.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: February 26, 2008
    Assignee: L'Air Liquide, Societe Anonyme a Directoire et Conseil de Surveillance pour l'Etude et l'Exploitation des Procedes Georges Claude
    Inventors: Philippe Campo, Jérôme Cluzeau, Christian Jalbert
  • Process for reducing sludge derived from the treatment of wastewater by oxygenation and mechanical action
    Patent number: 7147780
    Abstract: A method for reducing the production of sludge derived from the treatment of wastewater. The sludge is subjected to a mechanical action in the presence of a gas containing oxygen. The mechanical action is performed in such a way as to destroy the cell walls of between 5% and 80% of the microorganisms present in the sludge.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: December 12, 2006
    Assignee: L'Air Liquide, Société Anonyme à Directoire et Conseil de Surveillance pour l'Étude et l'Exploitation des Procédés Georges Claude
    Inventors: Philippe Campo, Jérôme Cluzeau
  • Method for reducing sludge of a biological ozone treatment system
    Publication number: 20060086661
    Abstract: Methods for treating aqueous effluent, which include reducing sludge formation during the biological treatment of an aqueous effluent. The sludge formation is reduced by injecting an ozone containing gas into an aeration tank which contains the effluent. The affluent is in contact with microorganisms in the tank at least once during the method. The ozone containing gas contains at least 2.5 mg of ozone per liter of the gas.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 27, 2006
    Inventors: Philippe Campo, Jerome Cluzeau, Christian Jalbert
  • Process for reducing sludge derived from the treatment of wastewater by oxygenation and mechanical action
    Publication number: 20050133445
    Abstract: A method for reducing the production of sludge derived from the treatment of wastewater. The sludge is subjected to a mechanical action in the presence of a gas containing oxygen. The mechanical action is performed in such a way as to destroy the cell walls of between 5% and 80% of the microorganisms present in the sludge.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 23, 2005
    Inventors: Philippe Campo, Jerome Cluzeau