Patents by Inventor Jerome Gonzalez
Jerome Gonzalez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20100240658Abstract: The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, W, Q and S have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.Type: ApplicationFiled: October 1, 2008Publication date: September 23, 2010Applicant: MERCK SERONO SAInventors: Anna Quattropani, Cyril Montagne, Wolfgang Sauer, Stefano Crosignani, Agnes Bombrun, Mathilde Muzerelle, Jerome Dorbais, Delphine Marin, Jerome Gonzalez, Patrick Gerber
-
Patent number: 7592477Abstract: The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of substituted methylene amide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs. Also the present invention relates to a method of treating diabetes type II, obesity and to regulate the appetite of mammals. The present invention is furthermore related to novel substituted methylene amide derivatives and method of preparation thereof. Formula (I).Type: GrantFiled: January 27, 2003Date of Patent: September 22, 2009Assignee: Laboratoires Serono SAInventors: Dominique Swinnen, Agnes Bombrun, Jerome Gonzalez, Patrick Gerber, Pierre-Andre Pittet
-
Patent number: 7589232Abstract: The present invention is related to alkynyl aryl carboxamides of Formula (I?) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia-hypercholesterolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkynyl aryl carboxamides of Formula (I?) to modulate, notably to inhibit the activity of PTPs. (I?) A is a C2-C15 alkynyl, C2-C6-alkynyl aryl, C2-C6-alkynyl heteroaryl. Cy is an aryl, heteroaryl, cycloalkyl or heterocycle group; n is either 0 or 1. Cy? is an aryl, which may optionally be fused by a 3-8 membered cycloalkyl. R1 and R2 are independently from each other is selected from the group consisting of hydrogen or (C1-C6)alkyl. R4 and R5 are each independently from each other selected from the group consisting of H, hydroxy.Type: GrantFiled: July 20, 2004Date of Patent: September 15, 2009Assignee: Laboratories Serono S.A.Inventors: Dominique Swinnen, Patrick Gerber, Jerome Gonzalez, Agnes Bombrun, Catherine Jorand-Lebrun
-
Publication number: 20090149652Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.Type: ApplicationFiled: May 2, 2008Publication date: June 11, 2009Inventors: Christophe Thurieau, Jerome Gonzalez, Christophe Moinet
-
Publication number: 20090029903Abstract: The present invention is related to carboxylic acids of Formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of carboxylic acids of Formula (I) to modulate, notably to inhibit the activity of PTPs.Type: ApplicationFiled: March 29, 2005Publication date: January 29, 2009Inventors: Dominique Swinnen, Catherine Jorand-Lebrun, Patrick Gerber, Jerome Gonzalez, Agnes Bombrun
-
Publication number: 20090018169Abstract: This present invention is related to sulfonamide derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of bacterial infections such as tuberculosis.Type: ApplicationFiled: February 9, 2007Publication date: January 15, 2009Applicant: Laboratoires Serono SAInventors: Jerome Gonzalez, Dominique Swinnen, Agnes Bombrun, Rob Hooft Van Huijsduijnen, Timothy Wells
-
Publication number: 20080275060Abstract: The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.Type: ApplicationFiled: November 16, 2006Publication date: November 6, 2008Applicant: LABORATOIRES SERONO SAInventors: Dominique Swinnen, Jerome Gonzalez
-
Publication number: 20080253339Abstract: Local radiocommunication device comprising an IP access point adapted to communicate outwards from the network in IP mode, a point-to-point communication module adapted to communicate with a terminal according to at least one point-to-point communication protocol, and an interface adapted to allow the IP access point to communicate with the point-to-point communication module and thus to allow the said terminal to communicate with the outside of the local radiocommunication network.Type: ApplicationFiled: March 17, 2005Publication date: October 16, 2008Inventors: David Libault, Jerome Gonzalez, Eric Carreel
-
Patent number: 7393861Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.Type: GrantFiled: May 4, 2005Date of Patent: July 1, 2008Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Christophe Thurieau, Jérôme Gonzalez, Christophe Moinet
-
Publication number: 20080090838Abstract: The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic 5 obstructive pulmonary disease, liver and pulmonary fibrosis.Type: ApplicationFiled: January 27, 2006Publication date: April 17, 2008Applicant: Laboratoires Serono S.A.Inventors: Dominique Swinnen, Jerome Gonzalez
-
Publication number: 20080021028Abstract: The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.Type: ApplicationFiled: July 25, 2005Publication date: January 24, 2008Applicant: Applied Research Systems ARS Holding N.V.Inventors: Dominique Swinnen, Agnes Bombrun, Jerome Gonzalez, Stefano Crosignani, Patrick Gerber, Catherine Jorand-Lebrun
-
Publication number: 20070105913Abstract: The present invention is related to alkynyl aryl carboxamides of Formula (I?) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia-hypercholesterolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkynyl aryl carboxamides of Formula (I?) to modulate, notably to inhibit the activity of PTPs. (I?) A is a C2-C15 alkynyl, C2-C6-alkynyl aryl, C2-C6-alkynyl heteroaryl. Cy is an aryl, heteroaryl, cycloalkyl or heterocycle group; n is either 0 or 1. Cy? is an aryl., which may optionally be fused by a 3-8 membered cycloalkyl. R1 and R2 are independently from each other is selected from the group consisting of hydrogen or (C1-C6)alkyl. R4and R5 are each independently from each other selected from the group consisting of H, hydroxy.Type: ApplicationFiled: July 20, 2004Publication date: May 10, 2007Applicant: Applied Research Systems ARS Holdings N.V.Inventors: Dominique Swinnen, Patrick Gerber, Jerome Gonzalez, Agnes Bombrun, Catherine Jorand-Lebrun
-
Patent number: 7115634Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.Type: GrantFiled: December 13, 2000Date of Patent: October 3, 2006Assignee: Societe de Conseils de Recherches et d'Applications ScientifiquesInventors: Christophe Thurieau, Jérôme Gonzalez, Christophe Moinet
-
Publication number: 20050239796Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.Type: ApplicationFiled: May 4, 2005Publication date: October 27, 2005Inventors: Christophe Thurieau, Jerome Gonzalez, Christophe Moinet
-
Publication number: 20050124656Abstract: The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of substituted methylene amide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs. Also the present invention relates to a method of treating diabetes type II, obesity and to regulate the appetite of mammals. The present invention is furthermore related to novel substituted methylene amide derivatives and method of preparation thereof. Formula (I).Type: ApplicationFiled: January 27, 2003Publication date: June 9, 2005Applicant: APPLIED RESEARCH SYSTEMS ARSInventors: Dominique Swinnen, Agnes Bombrun, Jerome Gonzalez, Patrick Gerber, Pierre-Andre Pittet
-
Publication number: 20040220188Abstract: The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl.Type: ApplicationFiled: May 21, 2004Publication date: November 4, 2004Inventors: Agnes Bombrun, Thomas Rueckle, Dominique Swinnen, Jerome Gonzalez, Dennis Church
-
Publication number: 20040006089Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula 1Type: ApplicationFiled: May 23, 2002Publication date: January 8, 2004Inventors: Christophe Thurieau, Jerome Gonzalez, Christhope Moinet