Abstract: An article of footwear and method of manufacturing an article of footwear comprises an upper, a sole structure adjacent the upper and a thermoplastic material sheet attached to the upper to fixedly secure one or more components to the upper or fixedly secure the upper to a sole structure where the thermoplastic material sheet provides the primary or only means for securing the components to the upper and the upper to the sole structure.

Abstract: An article of footwear and method of manufacturing an article of footwear comprises an upper, a sole structure adjacent the upper and a thermoplastic material sheet attached to the upper to fixedly secure one or more components to the upper or fixedly secure the upper to a sole structure where the thermoplastic material sheet provides the primary or only means for securing the components to the upper and the upper to the sole structure.

Abstract: An insole for a shoe is characterized by a cushioning device that circulates air between a plastic bottom layer and a soft, porous upper layer. The air is directed to designated areas of the insole via vertical apertures, which circulate air to and over the foot of a user. The bottom layer is formed with air capturing structures that when collapsed expel air that is forced through the apertures and to the surface of the user's foot. The bottom layer and the upper layer are separated by a porous middle layer that may be foam or other light weight but breathable material.

Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.

Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.

Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.

Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.

Abstract: This invention relates to a method of detecting and diagnosing neurological disease or dysfunction using antibodies against a neurological form of Pancreatic Thread Protein (nPTP). Specifically, this invention is directed to a method of diagnosing Alzheimer's Disease, Down's Syndrome, and other neurological diseases or dysfunctions by using monoclonal antibodies, combination of those monoclonal antibodies or nucleic acid probes, to detect nPTP. The invention also relates to a recombinant DNA molecule encoding PTP and to the substantially pure form of nPTP. The invention additionally relates to a method of diagnosing pancreatic disease using antibodies against Pancreatic Thread Protein.

Abstract: The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.

Abstract: This invention relates to a prosthetic replacement for the cornea and particularly to a transparent collagen material useful for making such a prosthesis and to methods for making such transparent collagen material. The prosthesis is preferably composed of a native, non-fibrilized, transparent collagen material formed from a soluble collagen solution by ultracentrifuging to form a pellet and fixing the same pellet, whereby the collagen material has less than 5% absorbance of light at 900 nm for a 5 mm thick sample and comprises polyhydroxyethylmethacrylate or vitrosin, in a range of from 0.01 to 50.0 percent by weight, based on the collagen protein.

Abstract: A transparent native, non-fibrilized collagen material is described having an absorbence at a wavelength of 900 nm of less than 5% in a sample 5 mm thick. This collagen material is useful for a prosthetic replacement of the cornea because of the high transparency and because it is a native material, and thus less susceptible to immunogenic responses. A method for forming the native, non-fibrilized, highly transparent collagen material comprises ultracentrifuging a purified solution of native collagen to form a pellet of transparent collagen material, and fixing the pellet of collagen material to form a rigid, leather-like material. The collagen material can also be used for prosthetic replacement of other bodily tissues, such as nucleus pulposus, cartilage, and vitreous body.