Patents by Inventor Jerome Hert

Jerome Hert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
    Publication number: 20200199155
    Abstract: Compounds of formula (I) wherein R1, R2, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Daniel HUNZIKER, Jerome HERT, Holger KUEHNE, Patrizio MATTEI, Markus RUDOLPH
  • Bicyclic quinazolinone derivatives
    Patent number: 10676446
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 9, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Christoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz
  • Bicyclic derivatives
    Patent number: 10669268
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: June 2, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Patrizio Mattei, Harald Mauser, Guozhi Tang, Lisha Wang
  • Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Patent number: 10669285
    Abstract: Compounds of formula (I) wherein R1, R2, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: June 2, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Daniel Hunziker, Jerome Hert, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Patent number: 10654857
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 19, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • Bicyclic compounds as dual ATX/CA inhibitors
    Patent number: 10647719
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 12, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Christoph Ullmer
  • Phenoxymethyl derivatives
    Patent number: 10640472
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: May 5, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Holger Kuehne, Thomas Luebbers, Rainer E. Martin, Patrizio Mattei, Werner Neidhart, Hans Richter, Markus Rudolph, Emmanuel Pinard
  • BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200087307
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 19, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Jerome Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200079779
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 12, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz
  • PEPTIDE MACROCYCLES AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20200040032
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R8?, R9, R9?, X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baurnannii.
    Type: Application
    Filed: October 8, 2019
    Publication date: February 6, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Konrad BLEICHER, Jérôme HERT, Carsten KROLL, Fabian DEY
  • HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS
    Publication number: 20200002297
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio MATTEI, Jérôme HERT, Daniel HUNZIKER, Markus RUDOLPH, Petra SCHMITZ, Patrick DI GIORGIO, Justin GOMME
  • BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200002336
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jérôme HERT, Daniel HUNZIKER, Patrizio MATTEI, Markus RUDOLPH, Petra SCHMITZ, Patrick DI GIORGIO
  • BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
    Publication number: 20190144457
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 16, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20180312515
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 23, 2018
    Publication date: November 1, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Jerome Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL
    Publication number: 20180280352
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Daniel Hunziker, Patrick Di Giorgio, Jerome Hert, Markus Rudolph, Lisha Wang
  • NEW OCTAHYDRO-PYRROLO[3,4-c]-PYRROLE DERIVATIVES AND ANALOGS THEREOF AS AUTOTAXIN INHIBITORS
    Publication number: 20180258095
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 9, 2018
    Publication date: September 13, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Patrizio Mattei, Harald Mauser, Guozhi Tang, Lisha Wang
  • NEW BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS
    Publication number: 20180215765
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 23, 2018
    Publication date: August 2, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Christoph Ullmer
  • NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20180208602
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 26, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz
  • BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS
    Publication number: 20180208601
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 26, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Christoph Ullmer
  • PHENOXYMETHYL DERIVATIVES
    Publication number: 20180201588
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 2, 2018
    Publication date: July 19, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Holger Kuehne, Thomas Luebbers, Rainer E. Martin, Patrizio Mattei, Werner Neidhart, Hans Richter, Markus Rudolph