Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: Various methods, apparatuses/systems, and media for automatically upgrading an application are disclosed. A processor creates a dynamic machine learning (ML) model; trains the dynamic ML model and scans for SDK upgrade for the application against the dynamic ML model by implementing ML algorithm for predictions. The processor executes the SDK upgrade in response to detecting that the training of the dynamic ML model is completed to trigger the processor to perform the following automated processes: implement the ML algorithm against the trained dynamic ML model to generate predictive results data for deprecated reference corresponding to the application; evaluate the predictive results data to determine whether there is a match for the deprecated reference; and when it is determined that there is a match for the deprecated reference, automatically replace code and upgrade the application to newer version of the programming language specification.

Abstract: Various methods, apparatuses/systems, and media for automatically detecting discrepancy between preset data and input data are provided. A processor implements a platform and language agnostic smart data discrepancy detection module that automatically detects discrepancy between preset data and input data (i.e., larger than the preset data) during data processing of a commercial transaction involving a gratuity, particularly when a credit card payment is being made. The processor also implements an optimized processes of conducting a commercial transaction that includes a gratuity data based on user preferences that are obtainable from an application during execution thereof, and automatically alerts the user when data discrepancy is detected, i.e., when the gratuity data is more than preset gratuity data set by the user on the application.

Abstract: A method and a system for detecting suspicious transactions and providing warnings in advance of executing the transactions in order to prevent fraud are provided. The method includes: receiving a request to conduct a transaction with an entity by using a digital payment application, the request including first profile information that relates to the entity; retrieving second profile information that relates to the requestor; comparing the first profile information with the second profile information; and determining, based on a result of the comparison, whether to suspend the requested transaction. When a determination is made that the proposed transaction may be fraudulent, the transaction may be suspended and a warning message may be sent to the requestor in order to afford an opportunity to avoid the fraud.

Abstract: Methods of enhancing efficiency of downstream chromatography steps for purification of proteins comprising: (a) passing a composition comprising a polypeptide of interest and various contaminants through an ion exchange membrane, wherein the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pi of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and at least one contaminant, (b) overloading the ion exchange membrane such that at least one contaminant remains bound to the membrane while the polypeptide of interest is primarily in the effluent; (c) collecting the effluent from the ion exchange membrane comprising the polypeptide of interest; (d) subjecting the membrane effluent comprising the polypeptide of interest to a purification step of similar charge as the previous membrane,

Abstract: Systems and methods for automated remediation of check data errors are disclosed. In one embodiment, a method for automated remediation of check data errors may include: (1) receiving, by a routing computer program, a check image from an acquisition channel; (2) extracting, by an extraction computer program, transaction information from the check image; (3) determining, by the routing computer program, that there is an error in the transaction information; (4) identifying, by a remediation computer program, a correction for the error a confidence score in the correction using a trained machine learning correction engine; and (5) correcting, by the remediation computer program, the error with the correction in response to the confidence score being above a confidence score threshold.

Abstract: A method and a system for detecting suspicious transactions and providing warnings in advance of executing the transactions in order to prevent fraud are provided. The method includes: receiving a request to conduct a transaction with an entity by using a digital payment application, the request including first profile information that relates to the entity; retrieving second profile information that relates to the requestor; comparing the first profile information with the second profile information; and determining, based on a result of the comparison, whether to suspend the requested transaction. When a determination is made that the proposed transaction may be fraudulent, the transaction may be suspended and a warning message may be sent to the requestor in order to afford an opportunity to avoid the fraud.

Abstract: Methods of enhancing efficiency of downstream chromatography steps for purification of proteins comprising: (a) passing a composition comprising a polypeptide of interest and various contaminants through an ion exchange membrane, wherein the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pi of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and at least one contaminant, (b) overloading the ion exchange membrane such that at least one contaminant remains bound to the membrane while the polypeptide of interest is primarily in the effluent; (c) collecting the effluent from the ion exchange membrane comprising the polypeptide of interest; (d) subjecting the membrane effluent comprising the polypeptide of interest to a purification step of similar charge as the previous membrane,

Abstract: A method for facilitating intelligent itinerary management via a progressive reservation system is disclosed. The method includes aggregating itinerary information for a user from user transactions, the itinerary information corresponding to a transit reservation; continuously monitoring, in real-time via an application programming interface, the transit reservation by using the itinerary information; determining, based on a result of the continuous monitoring, whether parameters that correspond to the transit reservation satisfy a predetermined threshold, the parameters including an operational status; automatically retrieving, from a repository, historical information that corresponds to the user when the parameters satisfy the predetermined threshold; automatically identifying, in real-time using a model, a future transit reservation based on the itinerary information and the historical information; and providing, via a graphical user interface, the identified future transit reservation to the user.

Abstract: Methods for preparing mammalian cells for perfusion cell culture processes that improve the growth and productivity of the cells are provided. Also provided are cell culture methods that involve subjecting mammalian cells to one or more perfusion procedures, which involve generating a solids phase and a liquid phase with a continuous flow centrifuge, and utilizing at least a portion of the solids phase to sustain, maintain and/or initiate a new cell culture. Perfusion bioreactor systems and components thereof are also provided.

Abstract: Various methods, apparatuses/systems, and media for automatically detecting discrepancy between preset data and input data are provided. A processor implements a platform and language agnostic smart data discrepancy detection module that automatically detects discrepancy between preset data and input data (i.e., larger than the preset data) during data processing of a commercial transaction involving a gratuity, particularly when a credit card payment is being made. The processor also implements an optimized processes of conducting a commercial transaction that includes a gratuity data based on user preferences that are obtainable from an application during execution thereof, and automatically alerts the user when data discrepancy is detected, i.e., when the gratuity data is more than preset gratuity data set by the user on the application.