Abstract: The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.

Abstract: The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.

Abstract: According to the method to measure in real-time the phase of a pseudo-periodic physiological signal of a user: one provides a physiological signal of the user;—a trigonometric function determination module of a processor determines parameters of a trigonometric function, which minimize a distance between the physiological signal and the trigonometric function on the time interval ]ta; tb[; and—a phase determination module of a processor determines the phase of the physiological signal at time tb based on the phase of the trigonometric function at time tb.

Abstract: The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.

Abstract: Disclosed is a method and device for determining a robust synthetic signal indicative of a bioelectrical activity of an individual. Two measurement signals representative of physiological electrical signals of an individual are continuously acquired by electrodes. Two time series of confidence indices associated with the measurement signals are constructed. A synthetic signal is determined from the measurement signals and from the time series of confidence indices.

Abstract: The method for commanding the production of an acoustic waveform based on a physiological control signal, includes: one provides sampled sound data including S sound samples stored on a data carrier; repeatedly, for n successive respective time intervals [tn; tn+1[ between an initial time ta and a final time tb: one provides a physiological control signal phi(t) as a function of time, during the current time interval [tn; tn+1[; a rate determination module of a processor determines a rate rn of samples to be played during that time interval based on a value phi (tn) of the physiological control signal at time tn; a command module of the processor commands the play of a part of the acoustic waveform from the sampled sound data as a function of the determined rate rn of samples.

Abstract: The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.

Abstract: A method and apparatus for processing or compressing an n-dimensional digital signal by constructing a sparse representation which takes advantage of the signal geometrical regularity. The invention comprises a warped wavelet packet transform which performs a cascade of warped subband filtering along warping grids of sampling points adapted to the signal geometry. It also comprises a bandeletisation which decorrelates the warped wavelet packet coefficients to produce a sparse representation. An inverse warped wavelet packet transform and an inverse bandeletisation reconstruct a signal from its bandelet representation. The invention comprises a compression system which quantizes and codes the bandelet representation, a decompression system, a restoration system which enhances a signal by filtering its bandelet representation, and a feature vector extraction system for pattern recognition applications of a bandelet representation.

Abstract: A method and apparatus for processing or compressing an n-dimensional digital signal by constructing a sparse representation which takes advantage of the signal geometrical regularity. The invention comprises a warped wavelet packet transform which performs a cascade of warped subband filtering along warping grids of sampling points adapted to the signal geometry. It also comprises a bandeletisation which decorrelates the warped wavelet packet coefficients to produce a sparse representation. An inverse warped wavelet packet transform and an inverse bandeletisation reconstruct a signal from its bandelet representation. The invention comprises a compression system which quantizes and codes the bandelet representation, a decompression system, a restoration system which enhances a signal by filtering its bandelet representation, and a feature vector extraction system for pattern recognition applications of a bandelet representation.

Abstract: A method and apparatus for processing or compressing an n-dimensional digital signal by constructing a sparse representation which takes advantage of the signal geometrical regularity. The invention comprises a warped wavelet packet transform which performs a cascade of warped subband filtering along warping grids of sampling points adapted to the signal geometry. It also comprises a bandeletisation which decorrelates the warped wavelet packet coefficients to produce a sparse representation. An inverse warped wavelet packet transform and an inverse bandeletisation reconstruct a signal from its bandelet representation. The invention comprises a compression system which quantizes and codes the bandelet representation, a decompression system, a restoration system which enhances a signal by filtering its bandelet representation, and a feature vector extraction system for pattern recognition applications of a bandelet representation.

Abstract: A method for determining impedance coefficients of a seismic trace comprises determining reflection coefficients of the seismic trace, for example using a sparse spike inversion, integrating the reflection coefficients with respect to time to obtain impedance coefficients, and filtering the impedance coefficients by applying a low-cut window filter. The window size and/or shape may be defined by a variable parameter which may be either specified by a user or optimized on the basis of a lateral variability parameter calculated for different values of the window parameter.

Abstract: A method for determining impedance coefficients of a seismic trace comprises determining reflection coefficients of the seismic trace, for example using a sparse spike inversion, integrating the reflection coefficients with respect to time to obtain impedance coefficients, and filtering the impedance coefficients by applying a low-cut window filter. The window size and/or shape may be defined by a variable parameter which may be either specified by a user or optimised on the basis of a lateral variability parameter calculated for different values of the window parameter.

Abstract: The invention relates to a method of high-resolution mapping of a heart, including: providing a heart mapping apparatus; contacting at least a portion of an intact heart tissue with a voltage-sensitive fluoroscopic dye to generate at least a portion of dyed heart tissue; inserting a first end of the heart mapping apparatus into an intact heart; illuminating the portion of dyed heart tissue with a first range of wavelengths of electromagnetic radiation from the first end of the heart mapping apparatus; collecting a second range of wavelengths of electromagnetic radiation from the portion of dyed heart tissue; and transforming the second range of wavelengths of electromagnetic radiation to at least about 100 points of information, wherein said 100 points of information yields a map of at least one anatomical feature and at least one electrical potential.

Abstract: Techniques for tomographic reconstruction using non-linear diagonal estimators are disclosed. In a preferred embodiment, tomographic data from a tomographic device is decomposed in a wavelet vector family. Regularization of the tomographic data is accomplished by performing a thresholding operation on coefficients of the decomposed data. The regularized data is reconstructed into image data that may he displayed. In another preferred embodiment, a wavelet packet vector family is used to decompose the tomographic data. The wavelet packet is selected from a dictionary of wavelet packets using the best basis algorithm.

Abstract: A method and apparatus for processing or compressing an n-dimensional digital signal by constructing a sparse rep resentation which takes advantage of the signal geometrical regularity. The invention comprises a warped wavelet packet transform which performs a cascade of warped subband filtering along wraping grids of sampling points adapted to the signal geometry. It also comprises a bandeletisation which decorrelates the warped wavelet packet coefficients to produce a sparse representation. An inverse warped wavelet packet transform and an inverse bandeletisation reconstruct a signal from its bandelet representation. The invention comprises a compression system which quantizes and codes the bandelet representation, a decompression system, a restoration system which enhances a signal by filtering its bandelet representation, and a feature vector extraction system for pattern recognition applications of a bandelet representation.

Abstract: Techniques for tomographic reconstruction using non-linear diagonal estimators are disclosed. In a preferred embodiment, tomographic data from a tomographic device is decomposed in a wavelet vector family. Regularization of the tomographic data is accomplished by performing a thresholding operation on coefficients of the decomposed data. The regularized data is reconstructed into image data that may he displayed. In another preferred embodiment, a wavelet packet vector family is used to decompose the tomographic data. The wavelet packet is selected from a dictionary of wavelet packets using the best basis algorithm.