Patents by Inventor Jerome Linder

Jerome Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing glycine hydrochloride
    Patent number: 4988789
    Abstract: An improved process for preparing glycine hydrochloride in a high purity and high yield employing water as the solvent.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: January 29, 1991
    Assignee: Sandoz Ltd.
    Inventor: Jerome Linder
  • Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
    Patent number: 4870199
    Abstract: Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P.sub.1 is independently an hydroxy group-protecting group, andR.sub.2z is C.sub.1-4 alkyl, benzyl or allyl,comprising, as a key step when R.sub.2z is R.sub.2x, the reaction of the compound of the formula ##STR2## in (S) enantiomeric form with a compound of the formulaMg.sup. .circle.+2 (.sup..crclbar. OOC--CH.sub.2 --COOR.sub.2x).sub.2to obtain a compound of the formula ##STR3## in (S) enantiomeric form, and, as a key step when R.sub.2z is R.sub.2y, the reaction of a compound of the formula ##STR4## in (S) enantioimeric form with a compound of the formulaLi.sup..sym..crclbar. CH.sub.2 --COOR.sub.2yto obtain a compound of the formula ##STR5## in (S) enantiomeric form, wherein R.sub.2x is primary or secondary C.sub.1-4 alkyl, benzyl or allyl,R.sub.2y is C.sub.1-4 alkyl not containing an asymmetric carbon atom, andR.sub.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: September 26, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventors: Kau-Ming Chen, Goetz E. Hardtmann, Prasad K. Kapa, George T. Lee, Jerome Linder, Sompong Wattanasin
  • Dibromination process
    Patent number: 4021492
    Abstract: The .alpha.,.alpha.-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.,.alpha.-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125.degree. C.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: May 3, 1977
    Assignee: Sandoz, Inc.
    Inventors: Jerome Linder, William J. Houlihan
  • 5-Hydrazinopyridazin-3(2H)-ones
    Patent number: 4002751
    Abstract: Substituted 5-hydrazinopyridazin-3(2H)-ones, e.g., 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H) -one or 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyrida zin-3(2H)-one, are prepared by treating halogenated pyridazin-3-(2H)-ones with hydrazine and substituted hydrazines and are useful as central nervous system depressants and sleep inducers.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: January 11, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jerome Linder
  • Bromination process
    Patent number: 3962342
    Abstract: The .alpha.-bromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.-bromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 100.degree.C.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: June 8, 1976
    Assignee: Sandoz, Inc.
    Inventors: Jerome Linder, William J. Houlihan
  • Preparation of 1-aryl-4,5-dihalo-pyridazone-6
    Patent number: 3935210
    Abstract: Disclosed is single phase multi-stage process for preparation of 1-aryl-4,5-dihalo-pyridazones-6 involving the diazotization of an amino aryl compound, e.g. aniline, followed by reduction with sulfurous acid to obtain the corresponding aryl hydrazine which is then reacted at elevated temperatures with a mucohalic acid to obtain the 1-aryl-4,5-dihalo-pyridazone-6.
    Type: Grant
    Filed: May 20, 1974
    Date of Patent: January 27, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jerome Linder