Patents by Inventor Jerome M. Bailey

Jerome M. Bailey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-terminal sequencing of peptides which may include proline
    Patent number: 5998213
    Abstract: A carboxy terminal protein sequencing process is disclosed which utilizes diphenyl phosphoroisothiocyanatidate and a heterocyclic amine to produce a thiohydantoin derivative of the C-terminal amino acid. The derivative is readily cleaved. The method is useful to sequence through all of the 20 naturally occuring amino acids.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: December 7, 1999
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • Sequencing of protein immobilized on polytetrafluoroethylene supports
    Patent number: 5541114
    Abstract: A method for sequencing proteins on a polytetrafluoroethylene support is described. The support is preferably porous. The sample to be sequenced may be transferred directly, e.g., by blotting, to the support. Covalent binding of the sample to the support is not required.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: July 30, 1996
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • N-terminal peptide degradation utilizing dialkylthiocarbamoylhalides
    Patent number: 5525707
    Abstract: An N-terminal peptide sequencing method is disclosed in which a thiocarbamoyl compound is reacted with N-terminal amino acid of the sample to form a derivative of said amino acid which is then cleaved.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: June 11, 1996
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • N-terminal sequencing of proteins and peptides
    Patent number: 5432091
    Abstract: An improved method for the N-terminal sequential degradation of proteins and peptides is disclosed. The protein or peptide to be sequenced is reacted with a compound effective to impart a tertiary amine functionality to the thiazolinone derivative of a cleaved terminal amino acid of the peptide.
    Type: Grant
    Filed: September 15, 1993
    Date of Patent: July 11, 1995
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • C-terminal peptide sequencing using diphenyl phosphoroisothiocyanatidate and pyridine
    Patent number: 5432092
    Abstract: A carboxy terminal protein sequencing process is disclosed which utilizes phosphoroisothiocyanatidate for the derivatization step.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: July 11, 1995
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • Sequential degradation of proteins and peptides from the N-terminus
    Patent number: 5432093
    Abstract: A novel method for the sequential degradation from the N-terminus of small samples of proteins or peptides. The released amino acids may be detected by mass spectrometry.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: July 11, 1995
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • Carboxylic acid modified polyethylene membrane activated by a linker coupled amide
    Patent number: 5306781
    Abstract: Activated carboxylic acid modified polyethylene membranes useful in the C-terminal sequencing of a peptide are disclosed. The membranes comprise activated carboxylic acid modified polyethylene having a linker coupled to an amide linkage to the surface carboxyl radicals of the membrane. Activation is accomplished by reaction of the carboxylic acid modified polyethylene membrane with DCC, CDI, EDC, BOP, DICD or 2-fluoro-1-methyl pyridine.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: April 26, 1994
    Assignee: City of Hope
    Inventor: Jerome M. Bailey
  • Sequential C-terminal degradation of peptides and proteins
    Patent number: 5254475
    Abstract: Reagents and method for the C-terminal sequencing of proteins and peptides are disclosed. The reagents include sodium trimethylsilanolate and trimethyl N-oxide. Derivatized, activated polyethylene supports for peptide samples subjected to C-terminal sequencing are described.
    Type: Grant
    Filed: May 31, 1992
    Date of Patent: October 19, 1993
    Assignee: City of Hope
    Inventor: Jerome M. Bailey
  • C-terminal peptide or protein sequencing reagent and method
    Patent number: 5180807
    Abstract: A carboxy terminal protein sequencing process is disclosed which utilizes phosphoroisothiocyanatidate for the derivatization step.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: January 19, 1993
    Assignee: City of Hope
    Inventors: Jerome M. Bailey, John E. Shively
  • Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
    Patent number: 5059540
    Abstract: Reagents useful for the C-terminal sequencing of proteins and peptides are disclosed. The reagents include sodium trimethylsilanolate and trimethyl N-oxide. The reagents are used as cleaving reagents in a method for the sequential C-terminal degradation of peptides and proteins.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: October 22, 1991
    Assignee: City of Hope
    Inventor: Jerome M. Bailey