Patents by Inventor Jerome M. Seyer

Jerome M. Seyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic peptide for treatment of autoimmune arthritis
    Patent number: 6423315
    Abstract: Peptides that are capable of suppressing autoimmune arthritis are disclosed. The polypeptides described by the present invention which are capable of suppressing autoimmune arthritis in mammals include analogues of CII 245-270. The peptides do not provoke a material immunogenic response from T cells, and thus are useful therapeutic agents for suppressing autoimmune arthritis, rheumatoid arthritis, juvenile arthritis, psoriatic arthritis, spondylo arthritis, relapsing polychondritis and other connective tissue diseases. A method of surpressing autoimmune arthritis in mammals is also provided by the present invention.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: July 23, 2002
    Assignee: The University of Tennessee Research Corp.
    Inventors: Linda K. Myers, Jerome M. Seyer, Andrew H. Kang
  • SYNTHETIC PEPTIDE FOR TREATMENT OF AUTOIMMUNE ARTHRITIS
    Publication number: 20020037844
    Abstract: Peptides for suppressing autoimmune arthritis by disrupting formation of trimolecular complexes which stimulate T cells.
    Type: Application
    Filed: April 20, 1995
    Publication date: March 28, 2002
    Inventors: LINDA K. MYERS, JEROME M. SEYER, ANDREW H. KANG
  • Method for treatment of systemic sclerosis and related fibrotic diseases
    Patent number: 5962025
    Abstract: The present invention is directed to a method and pharmaceutical formulations for the treatment of systemic sclerosis in mammals, by oral administration of collagen, including type I collagen, or biologically active peptide fragments thereof.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: October 5, 1999
    Assignee: The University of Tennessee Research Corporation
    Inventors: Laura Carbone, Andrew H. Kang, Kevin McKown, Arnold E. Postlethwaite, Jerome M. Seyer
  • Fragment of TNF-.alpha. for promoting wound healing
    Patent number: 5160483
    Abstract: A method and composition for promoting the healing of an open wound, such as a fresh surgical incision, a decubitus ulcer, or a diabetes ulcer. The method includes applying to the wound a therapeutically effective amount of a composition comprising a protein fragment of tumor necrosis factor .alpha.(TNF-.alpha.) including amino acids 31 through 68 SEQ ID NO.: 1. The composition may be applied topically or injected locally into a wound or ulcer site. A preferred composition includes a carrier medium selected from sterile water, sterile saline, and albumin. Topical formulations are administered as sprays, gels, ointments or salves.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: November 3, 1992
    Assignee: The University of Tennessee Research Corporation
    Inventors: Arnold E. Postlethwaite, Jerome M. Seyer, Andrew H. Kang
  • Somnogenic fragment of interleukin-1.beta.
    Patent number: 5075288
    Abstract: A protein fragment for inducing sleep in mammals comprising a fragment of interleukin-1 .beta. from about amino acid 208 to about amino acid 240 and its physiologically active derivatives. The fragment comprises the amino acids sequence: ##STR1## The protein fragment may be derived by synthetic methods and a cysteine residue may be attached to the last threonine residue.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: December 24, 1991
    Assignee: The University of Tennessee Research Corporation
    Inventors: James M. Krueger, Ferenc Obal, Jr., Arnold E. Postlethwaite, Jerome M. Seyer