Patents by Inventor Jerome Mathe

Jerome Mathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPORE SEQUENCING USING REPLICATIVE POLYMERASES AND HELICASES
    Publication number: 20160319344
    Abstract: The present invention relates to a system of nanopore sequencing using nucleic-acid binding proteins wherein the activity of the said protein and the passage of the sequenced nucleic acid molecule through the nanopore are coordinated. In particular, the present invention enables an easy synchronization of nanopore capture with polynucleotide unwinding, which in turn affords an easy way to repeat the whole process of capture and nucleotide characterization.
    Type: Application
    Filed: December 19, 2014
    Publication date: November 3, 2016
    Inventors: Vincent CROQUETTE, Maria MANOSAS, Jerome MATHE, David BENSIMON, Jean-Francois ALLEMAND
  • Ultra high-throughput opti-nanopore DNA readout platform
    Patent number: 8802838
    Abstract: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: August 12, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Amit Meller, Jerome Mathe, John S. Eid
  • ULTRA HIGH-THROUGHPUT OPTI-NANOPORE DNA READOUT PLATFORM
    Publication number: 20110257043
    Abstract: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 20, 2011
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Amit MELLER, Jerome MATHE, John S. EID
  • Ultra high-throughput opti-nanopore DNA readout platform
    Patent number: 7972858
    Abstract: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: July 5, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Amit Meller, Jerome Mathe, John S. Eid
  • Ultra High-Throughput Opti-Nanopore DNA Readout Platform
    Publication number: 20090029477
    Abstract: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.
    Type: Application
    Filed: August 12, 2005
    Publication date: January 29, 2009
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Amit Meller, Jerome Mathe, John S. Eid