Abstract: A system and method for automated lens adjustment for hyperspectral imaging is described. The system includes an image sensor and an electrically-controllable element arranged to set a spectral band for image capture by (i) selectively providing light for a selected spectral band or (ii) selectively filtering light to a selected spectral band. The system includes a tunable lens that is adjustable to change a focal length of the lens; and one or more data storage devices storing data that indicates different focus adjustment parameters corresponding to different spectral bands. The system includes a control system configured to perform operations including: selecting a spectral band; controlling the electrically-controllable element to set the spectral band for image capture; retrieving the focus adjustment parameter that corresponds to the spectral band; adjusting the lens based on the retrieved focus adjustment parameter; and capturing an image of the subject while the lens remains adjusted.