Patents by Inventor Jerome P. Horwitz
Jerome P. Horwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8183379Abstract: The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof, and methods of inhibiting cancer cells.Type: GrantFiled: November 14, 2008Date of Patent: May 22, 2012Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Lisa Polin, Stuart T. Hazeldine, Thomas H. Corbett
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Patent number: 7728007Abstract: The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: October 29, 2008Date of Patent: June 1, 2010Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
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Patent number: 7585863Abstract: The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: August 31, 2006Date of Patent: September 8, 2009Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
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Patent number: 7507749Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: May 24, 2007Date of Patent: March 24, 2009Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
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Publication number: 20090076073Abstract: The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: ApplicationFiled: October 29, 2008Publication date: March 19, 2009Inventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
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Publication number: 20090069372Abstract: The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof, and methods of inhibiting cancer cells.Type: ApplicationFiled: November 14, 2008Publication date: March 12, 2009Inventors: Jerome P. Horwitz, Lisa Polin
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Patent number: 7470788Abstract: The invention provides compounds of formula I: wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: September 9, 2005Date of Patent: December 30, 2008Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Lisa Polin, Stuart T. Hazeldine, Thomas H. Corbett
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Patent number: 7241894Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: December 10, 2004Date of Patent: July 10, 2007Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
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Patent number: 7109341Abstract: The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: July 3, 2003Date of Patent: September 19, 2006Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
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Patent number: 6867219Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: July 31, 2002Date of Patent: March 15, 2005Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
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Publication number: 20040132618Abstract: The invention provides compounds of the formula: 1Type: ApplicationFiled: July 3, 2003Publication date: July 8, 2004Inventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
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Publication number: 20030144321Abstract: The invention provides compounds of formula I: 1Type: ApplicationFiled: July 31, 2002Publication date: July 31, 2003Inventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
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Patent number: 4668668Abstract: A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms and Y is amino, inhibits the growth of murine ductal carcinoma (MXT mammary tumors). A compound wherein Z is OH and Y is nitro, administered orally, inhibits the growth of MXT mammary tumors.Type: GrantFiled: February 3, 1986Date of Patent: May 26, 1987Assignee: Wayne State UniversityInventors: Samuel C. Brooks, Jerome P. Horwitz
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Patent number: 4636496Abstract: A compound of the formula ##STR1## wherein Z is hydrogen and Y is nitro, inhibits the growth of murine ductal carcinoma (MXT mammary tumors).Type: GrantFiled: January 28, 1986Date of Patent: January 13, 1987Assignee: Wayne State UniversityInventors: Samuel C. Brooks, Jerome P. Horwitz
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Patent number: 4568673Abstract: A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms or hydroxyalkoxy of 2-4 carbon atoms and Y is nitro, inhibiting the growth of murine ductal carcinoma (MXT mammary tumors).Type: GrantFiled: March 20, 1984Date of Patent: February 4, 1986Assignee: Wayne State UniversityInventors: Samuel C. Brooks, Jerome P. Horwitz
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Patent number: 4496555Abstract: The present invention concerns the novel compounds having fluoro, amino, nitro or hydroxy monosubstituted at the 2- or 4- position on deoxyestrone as well as deoxyestra-17-ol. The compounds are useful as estrogen sulfotransferase inhibitors. Such estrogen sulfotransferase inhibition provides the novel use for treating a female mammal to prevent implantation of a blastocyst. Additionally, the invention concerns the novel synthesis and novel intermediates in the synthesis of the estrogen sulfotransferase inhibiting compound of the present invention.Type: GrantFiled: July 19, 1983Date of Patent: January 29, 1985Assignee: Wayne State UniversityInventors: Samuel C. Brooks, Jerome P. Horwitz
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Patent number: 4266048Abstract: Analogs of 3'-phosphoadenosine 5'-phosphosulfate, also known as PAPS, are useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding an analog B of a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present process an analog B is selected from 8-bromoadenine, purine, hypoxanthine, 4-aminopyrrolo[2,3-d]pyrimidine (tubercidin), and 7-amino-pyrazolopyrimidine (formycin). In the pilot procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T.sub.2, the desired compound, an analog of PAPS, is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase II or spleen phosphodiesterase.Type: GrantFiled: October 26, 1978Date of Patent: May 5, 1981Assignee: The United States of America as represented by the Department of Health, Education and WelfareInventors: Jerome P. Horwitz, John P. Neenan, Radhey S. Misra, Jurij Rozhin, Anne Huo, Kerstin D. Philips, deceased
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Patent number: 4169011Abstract: 3'-Phosphoadenosine 5'-phosphosulfate, also known as PAPS, is useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding 68-72% product from a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T.sub.2, the desired compound is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase or spleen phosphodiesterase. This latter compound, iso-PAPS, biologically has only one-third the activity of PAPS, the natural isomer.Type: GrantFiled: October 11, 1977Date of Patent: September 25, 1979Assignee: The United States of America as represented by the Department of Health, Education and WelfareInventors: Jerome P. Horwitz, John P. Neenan, Radhey S. Misra, Jurij Rozhin, Anne L. Huo, Kirsten D. Philips, deceased