Patents by Inventor Jerome Pinkner

Jerome Pinkner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACINETOBACTER VACCINE AND METHOD OF USE THEREOF
    Publication number: 20260191944
    Abstract: The present disclosure provides for a vaccine comprising an Acinetobacter adhesin protein or fragment thereof and a pharmaceutically acceptable carrier or adjuvant. The vaccine may be used for treating or preventing a urinary tract infection (UTI) in a subject in need thereof, particularly a catheter-associated UTI (CAUTI). In some embodiments, the Acinetobacter adhesin protein or fragment thereof is an isolated Acinetobacter chaperone-usher pathway (CUP) adhesin protein or immunogenic fragment thereof.
    Type: Application
    Filed: December 5, 2023
    Publication date: July 9, 2026
    Applicant: Washington University
    Inventors: Scott HULTGREN, Morgan TIMM, Kevin TAMADONFAR, Ali ELLEBEDY, Jerome PINKNER, Mario FELDMAN, Karen DODSON
  • FIMH INHIBITING COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250304662
    Abstract: Among the various aspects of the present disclosure is the provision of FimH inhibiting compositions and methods of use thereof. FimH inhibiting compositions that target and inhibit FimH, including monoclonal antibodies, are described. Methods of identifying FimH inhibiting antibodies are also described. Further, a method of treating bacterial infections, including urinary tract infections, is described.
    Type: Application
    Filed: April 1, 2025
    Publication date: October 2, 2025
    Applicant: Washington University
    Inventors: Scott Hultgren, Ali Ellebedy, Edward Lopatto, Karen Dodson, Jerome Pinkner, Morgan Timm, Shaza Sayed Ahmed, Isabella Fox, Denise Sanick, Nathaniel Gualberto, Andrew Kau, Jesus Santiago-Borges, Aaron Schmitz, Jackson Turner
  • STRUCTURAL BASIS FOR OUTER MEMBRANE USHER ACTIVATION TO CATALYZE P PILUS ASSEMBLY
    Publication number: 20200345707
    Abstract: Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that disrupt the intramolecular interactions of the pilus subunits thereby reducing pilus assembly.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 5, 2020
    Inventors: Scott HULTGREN, Natalie OMATTAGE, Fredrik ALMQVIST, Jerome PINKNER, Karen DODSON, Peng YUAN
  • Compositions and methods for the treatment and prevention of Ebp pilus-related diseases
    Patent number: 10449242
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: October 22, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES
    Publication number: 20180055923
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Application
    Filed: November 13, 2017
    Publication date: March 1, 2018
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • Compositions and methods for the treatment and prevention of Ebp pilus-related diseases
    Patent number: 9839682
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 12, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES
    Publication number: 20160074498
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 17, 2016
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • Amino methylated 2-pyridinones
    Publication number: 20070082887
    Abstract: Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit adherence of bacteria to a host cell.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 12, 2007
    Applicant: Washington University
    Inventors: Scott Hultgren, Jerome Pinkner, Fredrik Almqvist, Nils Pemberton, Veronica Aberg, Andreas Larsson