Patents by Inventor Jerome Siegel

Jerome Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Treating Pain While Minimizing the Risk of Opioid Addiction
    Publication number: 20230270739
    Abstract: Disclosed herein are compositions and methods for treating subjects for pain with opioids while reducing or inhibiting their risk of opioid addiction.
    Type: Application
    Filed: May 21, 2021
    Publication date: August 31, 2023
    Inventors: Jerome Siegel, Ronald McGregor, Ming-Fung Frank Wu
  • Administering hypocretin to obese individuals
    Patent number: 7662780
    Abstract: The invention provides compositions and methods for treatment and prophylaxis of weight disorders. Such methods entail administering to an individual a therapeutically or prophylactically effective dosage regime of a hypocretin or an agonist thereof, and monitoring the condition of the individual responsive to the administering.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: February 16, 2010
    Assignee: The Regents of the University of California
    Inventors: Jerome Siegel, Lisa Noelle Boehmer Murillo
  • ADMINISTRATION OF HYPOCRETIN-1 FOR TREATMENT OF NARCOLEPSY
    Publication number: 20070010445
    Abstract: The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a hypocretin 1 (Hcrt-1) receptor to a peripheral tissue of the patient, and monitoring the condition of the patient responsive to the treatment, wherein the monitoring indicates a reduction in excessive daytime sleepiness (EDS) and an improvement in nighttime sleep consolidation and architecture. The methods are particularly useful for prophylactic and therapeutic treatment of one or more sleep disorders in a patient.
    Type: Application
    Filed: July 31, 2006
    Publication date: January 11, 2007
    Applicant: The Regents of the University of California
    Inventors: Jerome Siegel, Joshi John, Ming-Fung Wu
  • Hypocretin administration as a treatment for obesity
    Publication number: 20060241029
    Abstract: The invention provides compositions and methods for treatment and prophylaxis of weight disorders. Such methods entail administering to an individual a therapeutically or prophylactically effective dosage regime of a hypocretin or an agonist thereof, and monitoring the condition of the individual responsive to the administering.
    Type: Application
    Filed: August 27, 2003
    Publication date: October 26, 2006
    Inventors: Jerome Siegel, Lisa Boehmer
  • Screening and therapeutic methods for treating circadian rhythm disorders
    Publication number: 20060172935
    Abstract: The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or agonist; and (b) determining the ability of the compound to modulate one or more indicia of circadian rhythm function, wherein a compound that modulates one or more indicia of circadian rhythm function is identified as a compound for modulating circadian rhythm. The invention also provides a mouse PK2 receptor nucleic acid, polypeptide and related compositions. Further provided is a method for modulating circadian rhythm of an animal, which involves administering an effective amount of a PK2 receptor antagonist or agonist to an animal. Also provided is an isolated nucleic acid comprising a PK2 gene promoter operatively linked to a heterologous nucleotide sequence.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 3, 2006
    Inventors: Qun-Yong Zhou, Clayton Bullock, Jerome Siegel