Abstract: Devices, systems, methods, and processes are described herein that can reduce network communication overhead by reducing data that is sent. This reduction in data can be achieved by reducing the requests for data related to the buffers of one or more network devices. This buffer status data reduction can be achieved by predicting the current status of the buffers in other network devices. When the buffer predictions are sufficient, the need to request or poll for buffer status reports can be reduced. The buffer predictions can be evaluated through one or more confidence levels. These buffer predictions and confidence levels can be generated by one or more machine learning processes that are configured to operate on one or more network devices. Based on the confidence levels of the predictions, the number of buffer status report polls and of any unsolicited buffer service reports can be reduced.

Abstract: A system and method for a quality of service target performance element for use in traffic flow scheduling. In one embodiment, a method includes receiving first information indicating a requested traffic class for an upstream traffic flow, determining one or more target performance characteristics associated with the requested traffic class, and scheduling network resources for the upstream traffic flow based on the one or more target performance characteristics.

Abstract: This application relates to a building energy analysis and management system for measurement and verification of building performance. The system can analyze, optimize, manage, maintain, trouble shoot, and/or modify building systems, such as HVAC systems, in connection with the building energy usage. Measurements may be gathered for one or more HVAC units coupled to pressure independent valves, and sent to one or more Surge Panels that pass data to remote analysis servers, which can receive other system or external data. The analysis servers compare measurements to predicted values and can standardize the predicted values to account for external conditions. The comparison can result in difference values used to generate probable causes and optimization recommendations. The system outputs reports or other data display using a graphical user interface that can be adjusted for an anticipated user.

Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4?) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.

Abstract: A method for parsing a document having a document type, where the document type has a corresponding type structure including a plurality of document components, comprising receiving a new document, determining the document type, and selecting a parser from a plurality of parsers based on the document type. The method continues with parsing the document into a tagged data structure using the selected document parser, where the tagged data structure corresponds to the type structure of the document. The populated tagged data structure is stored in a database and made available over a computer network. In some embodiments, the document converted to simplified XML prior to parsing.

Abstract: Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly.

Abstract: Embodiments of the disclosure relate to an optical fiber cable. The optical fiber cable includes a cable jacket having a first inner surface and a first outer surface. The first inner surface defines a central bore along a longitudinal axis of the optical fiber cable. The optical fiber cable also includes optical fibers disposed within the central bore and a buffer tube surrounding the optical fibers. The buffer tube has a second inner surface and a second outer surface. The optical fiber cable also includes an armor layer disposed between the first inner surface of the cable jacket and the second outer surface of the buffer tube and a water-blocking adhesive disposed between the armor layer and the first outer surface of the buffer tube. The water-blocking adhesive extends along the longitudinal axis of the optical fiber cable and around a circumference of the buffer tube.

Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4?) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.

Abstract: Described herein are oligonucleotides (e.g., single-stranded oligonucleotides) and compositions thereof for targeting a mutation in the spliceosome, such as the U 1 small nuclear RNA (snRNA), as well as related methods of use.

Abstract: The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.

Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4a) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.

Abstract: The present disclosure relates generally to methods and compositions for modulating frataxin (FXN) expression, e.g., to treat Friedreich ataxia (FRDA).

Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of an apolipoprotein B (APOB) gene by targeting an APOB expression control region and methods of use thereof for treating an APOB associated disorder, e.g., hypercholesterolemia.

Abstract: Methods, kits and devices for detecting antineoplastic drug contamination of a surface are provided according to aspects of the present invention. According to aspects of the invention, methods for detecting antineoplastic drug contamination of a surface include providing a wetting solution compatible with the antineoplastic drug and formulated to promote release of the drug from the surface to be assayed; providing a solid matrix for reversible absorption of the antineoplastic drug; contacting the solid matrix with the wetting solution, generating an assay matrix; contacting the assay matrix and the surface, generating a surface sample; contacting the surface sample with a volume of wetting solution, generating a fluid test sample; and quantifying the antineoplastic drug in the fluid test sample by lateral flow assay to produce an assay result, thereby detecting antineoplastic drug contamination of the surface.

Abstract: Methods, kits and devices for detecting antineoplastic drug contamination of a surface are provided according to aspects of the present invention. According to aspects of the invention, methods for detecting antineoplastic drug contamination of a surface include providing a wetting solution compatible with the antineoplastic drug and formulated to promote release of the drug from the surface to be assayed; providing a solid matrix for reversible absorption of the antineoplastic drug; contacting the solid matrix with the wetting solution, generating an assay matrix; contacting the assay matrix and the surface, generating a surface sample; contacting the surface sample with a volume of wetting solution, generating a fluid test sample; and quantifying the antineoplastic drug in the fluid test sample by lateral flow assay to produce an assay result, thereby detecting antineoplastic drug contamination of the surface.

Abstract: Computer-implemented methods can transform a corpus of meaningful text sequences into a generalized computer-usable repository of neurolinguistic information that can be applied by one or more computer systems. The computer system(s) can use the neurolinguistic information to neurolinguistically analyze meaningful text sequences to derive statistical information and identify dominant cognitive motivation orientations expressed in those text sequences. The identified dominant cognitive motivation orientations can be used to improve the efficacy of both human-generated and machine-generated communications. The computer system(s) thereby transform a meaningful text sequence into actionable information about the dominant cognitive motivation orientation(s) of the author of that text sequence within the context in which the text sequence was composed. Computer systems and computer-program products for implementing the methods are also described.

Abstract: Computer-implemented methods can transform a corpus of meaningful text sequences into a generalized computer-usable repository of neurolinguistic information that can be applied by one or more computer systems. The computer system(s) can use the neurolinguistic information to neurolinguistically analyze meaningful text sequences to derive statistical information and identify dominant cognitive motivation orientations expressed in those text sequences. The identified dominant cognitive motivation orientations can be used to improve the efficacy of both human-generated and machine-generated communications. The computer system(s) thereby transform a meaningful text sequence into actionable information about the dominant cognitive motivation orientation(s) of the author of that text sequence within the context in which the text sequence was composed. Computer systems and computer-program products for implementing the methods are also described.

Abstract: Computer-implemented methods can transform a corpus of meaningful text sequences into a generalized computer-usable repository of neurolinguistic information that can be applied by one or more computer systems. The computer system(s) can use the neurolinguistic information to neurolinguistically analyze meaningful text sequences to derive statistical information and identify dominant cognitive motivation orientations expressed in those text sequences. The identified dominant cognitive motivation orientations can be used to improve the efficacy of both human-generated and machine-generated communications. The computer system(s) thereby transform a meaningful text sequence into actionable information about the dominant cognitive motivation orientation(s) of the author of that text sequence within the context in which the text sequence was composed. Computer systems and computer-program products for implementing the methods are also described.

Abstract: Disclosed is a decorative cover for cleaning product containers. The device includes a cylindrical cover having a decorative ornamentation on its exterior surface. In some embodiments, the cover may also include decorative ornamentation on its interior surface to provide fluidity of content and design. The ornamentation is customizable so that the cover may be decorated with any pattern, image, or inscription. The cover has an open top and bottom configuration so as to allow a user to slide on the cover over an existing cleaning product container without requiring additional attachment means. The device is constructed to conceal the basic packaging disposed on the product containers. In this way, the present invention adds a decorative appeal to an otherwise basic packaging which may not be aesthetically appealing to consumers.

Abstract: Methods, kits and devices for detecting antineoplastic drug contamination of a surface are provided according to aspects of the present invention. According to aspects of the invention, methods for detecting antineoplastic drug contamination of a surface include providing a wetting solution compatible with the antineoplastic drug and formulated to promote release of the drug from the surface to be assayed; providing a solid matrix for reversible absorption of the antineoplastic drug; contacting the solid matrix with the wetting solution, generating an assay matrix; contacting the assay matrix and the surface, generating a surface sample; contacting the surface sample with a volume of wetting solution, generating a fluid test sample; and quantifying the antineoplastic drug in the fluid test sample by lateral flow assay to produce an assay result, thereby detecting antineoplastic drug contamination of the surface.