Patents by Inventor Jerome Strauss, III

Jerome Strauss, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the treatment of defects in lipoprotein metabolism
    Patent number: 7306794
    Abstract: The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: December 11, 2007
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Karen Kozarsky, Jerome Strauss, III
  • Methods and compositions for the treatment of defects in lipoprotein metabolism
    Patent number: 6887463
    Abstract: The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: May 3, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Karen Kozarsky, Jerome Strauss, III
  • Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
    Patent number: 6174527
    Abstract: The invention provides a recombinant viral vector comprising a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is usefuil in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: January 16, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Karen Kozarsky, Jerome Strauss, III
  • Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity
    Patent number: 6140099
    Abstract: The invention relates to compositions and methods for delaying the onset of fetal membrane rupture in a human. The method comprises administering to the human a metalloproteinase-9 inhibitor in an amount effective to delay the onset of fetal membrane rupture in the human.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 31, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Jerome Strauss, III
  • Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
    Patent number: 5652224
    Abstract: The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: July 29, 1997
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Karen Kozarsky, Jerome Strauss, III