Abstract: This disclosure relates to an adjustable deck system that may be moved to various positions inside a cargo container to provide a second cargo loading deck inside the cargo container. The adjustable deck system includes first and second decks that may be moved to various heights in the cargo container. The second deck is positioned at a rear portion of the cargo container, and a rear end of the second deck may be lowered from a raised position down to a floor position creating a ramp for loading cargo onto the first deck. In some examples, the entire second deck may be lowered and raised independently of the first deck to enable the second deck to operate as an elevator system. Automated lift and support assemblies are provided for controlling movement and support of the adjustable deck system to and at various positions inside the cargo container.

Abstract: A deck system for cargo compartment may including one or more of the following features: a first deck; a second deck, where at least one of the first deck and the second deck divide the cargo compartment into an upper sub-compartment and a lower sub-compartment; and an actuator that is mechanically coupled to the second deck, where operation of the actuator causes at least a portion of the second deck to move vertically relative to the first deck within the cargo compartment.

Abstract: A pharmaceutical product for administration of an anti TROP2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the anti-TROP2 antibody-drug conjugate and the ATR inhibitor are administered in combination to a subject: Formula (I).

Abstract: A pharmaceutical product for administration of an anti-TROP2 antibody-drug conjugate in combination with a PARP1 selective inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond.

Abstract: A system including an engine connectable to a time variant working load. A motor is connected to the engine, and a variable frequency drive is connected to the motor. A system controller is connected to the variable frequency drive, and is programmed to command the variable frequency drive to change a selected mode of the motor according to an operational state of the engine. An electrical generation mode includes the motor operating as a generation load on the engine when the working load falls to an intermediate load below the operational load. A generation load combined with the intermediate load includes about the operational load. A standby mode includes the motor operating as a standby load on the engine when the working load about equals the operational load. A drive mode includes the motor applying mechanical power to the engine.

Abstract: A deck system for cargo compartment may including one or more of the following features: a first deck; a second deck, where at least one of the first deck and the second deck divide the cargo compartment into an upper sub-compartment and a lower sub-compartment; and an actuator that is mechanically coupled to the second deck, where operation of the actuator causes at least a portion of the second deck to move vertically relative to the first deck within the cargo compartment.

Abstract: A deck system for cargo compartment may including one or more of the following features: a first deck; a second deck, where at least one of the first deck and the second deck divide the cargo compartment into an upper sub-compartment and a lower sub-compartment; and an actuator that is mechanically coupled to the second deck, where operation of the actuator causes at least a portion of the second deck to move vertically relative to the first deck within the cargo compartment.

Abstract: A pharmaceutical product for administration of an anti-HER2 antibody-drug conjugate in combination with a PARP1 selective inhibitor is provided. The anti-HER2 antibody drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the antibody-drug conjugate and the PARP1 selective inhibitor are administered in combination to a subject: Formula (I).

Abstract: A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond.

Abstract: A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with an ATM inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the antibody-drug conjugate and the ATM inhibitor are administered in combination to a subject: Formula (I).

Abstract: A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with a CDK9 inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond.

Abstract: Described are enclosures that include a friction stir weld, including electronic device enclosures, and precursors thereof that contain a metal base that includes a recess and a metal cover that in an assembled condition form a joint at which a friction stir weld can be produced, as well as methods for producing a friction stir weld at a joint of such an assembly; the base includes at least one bow wave reduction feature.

Abstract: A motorized horizontal support system may include first and second vertical tracks that are configured to be installed upon opposing walls of a cargo compartment; first and second brackets that each slide along the respective first and second vertical tracks; a horizontal support disposed between and fixed with respect to the first and second brackets, where the horizontal support includes a first inner passageway extending along a length of the horizontal support; a first balance cable extending through the first inner passageway of the horizontal support; a motor operatively engaged with the second bracket, where operation of the motor may cause the first and second brackets to slide upwardly or downwardly along the respective first and second vertical tracks; and a controller with user input capability that may selectively control the operation of the motor.

Abstract: A deck system for cargo compartment may including one or more of the following features: a first deck; a second deck, where at least one of the first deck and the second deck divide the cargo compartment into an upper sub-compartment and a lower sub-compartment; and an actuator that is mechanically coupled to the second deck, where operation of the actuator causes at least a portion of the second deck to move vertically relative to the first deck within the cargo compartment.

Abstract: Clamping devices and associated methods that are useful to develop both axial and circumferential clamping forces in response to a common axial clamping force. The clamp is able to use a simple mechanism to generate both kinds of clamping forces from a single, axial actuating force. The clamping devices of the present invention are particularly useful for clamping cover and base deck components of a hard disk drive enclosure together to allow the components to be joined and sealed together using welding techniques.

Abstract: The present invention relates to methods to join at least first and second metallic components in which a pre-treatment is applied to one or more region(s) of at least one of the components to be welded together before welding takes place. The pre-treatment involves contacting at least a region of the first metallic component with a rotating and translating tool such that the rotating and translating contact locally heats, softens, and mixes successive portions of at least the region of the first metallic component. The first and second metallic components are placed together such that a joint is provided between at least the pre-treated region of the first metallic component and the second metallic component. At least the pre-treated region of the first metallic component is welded to the second metallic component along at least a portion of the joint.

Abstract: Described are methods for forming a friction stir weld between a steel piece and an aluminum piece, with specific examples of the steel piece and the aluminum piece being a cover and a base of an enclosure.

Abstract: A method for making a hard disk drive is disclosed. The method includes forming a base deck comprising an aluminum alloy via vacuum casting. The method further includes subjecting the base deck to hot isostatic pressing. The method further includes welding a cover to the base deck.

Abstract: Described are enclosures that include a friction stir weld, including electronic device enclosures, and precursors thereof, that contain a base and a cover that in an assembled condition form a joint at which a friction stir weld can be produced, as well as methods for producing a friction stir weld at a joint of such an assembly.

Abstract: Described are enclosures that include a friction stir weld, including electronic device enclosures, and precursors thereof, that contain a base and a cover that in an assembled condition form a joint at which a friction stir weld can be produced, as well as methods for producing a friction stir weld at a joint of such an assembly.