Abstract: A simulation system performs microsimulations to model the impact of one or more early cancer detection screenings for a plurality of participants to simulate a randomized controlled trial (RCT). In one instance, the microsimulations are performed using parallel processing techniques. The microsimulation simulates the impact of early detection screenings on individual trajectories of the participants. In particular, while most screening modalities are for single cancer types, the microsimulation herein simulates the effect of a detection model on individual trajectories for participant populations having multiple types of cancer using, for example, multi-cancer early detection (MCED) screenings that are capable of detecting multiple types of cancer.

Abstract: The invention relates to a transmission module (10) for an engine-transmission unit, said module comprising an input shaft (11) for connecting to a heat engine, an output shaft (12) for connecting to a gearbox, and a clutch (30) connecting said two shafts. The inventive module also comprises: an independent casing (16) comprising a first half-shell (17) and a second half-shell (18), said two half-shells forming a sealed receiving element (22) containing the clutch (30) which is naturally in the engaged position; a mechanical element (35) for maintaining the clutch (30) in said engaged position by means of a piston in the form of a disk; a hydraulic control circuit (40, 41) for acting directly on the piston against the mechanical element, in the disengaged position of said clutch (30); and a hydraulic circuit (50, 52, 53, 55, 56) for lubricating and cooling the clutch. The invention can be applied to an engine-transmission unit for motor vehicles.

Abstract: The invention concerns an element comprising an electrical machine (31), two wet clutches (33, 35), a cooling fluid circuit, including a chamber (53) for cooling the clutches (33, 35), a fluid tank (251), and a pump (255). The pump (225) is connected to a recycling channel (259), the cooling circuit comprising selecting means (257) arranged upstream of the pump (255), such that said pump is capable of selectively feeding said chamber (53) from the tank (251) and from the recycling channel (259) based on the temperature of the fluid passing through the selecting means (257). The invention also concerns an associated cooling and/or lubricating, and clutch control method, as well as a motor vehicle equipped with such a transmission document.

Abstract: The invention relates to a transmission module (10) for an engine-transmission unit, said module comprising an input shaft (11) for connecting to a heat engine, an output shaft (12) for connecting to a gearbox, and a clutch (30) connecting said two shafts. The inventive module also comprises: an independent casing (16) comprising a first half-shell (17) and a second half-shell (18), said two half-shells forming a sealed receiving element (22) containing the clutch (30) which is naturally in the engaged position; a mechanical element (35) for maintaining the clutch (30) in said engaged position by means of a piston in the form of a disk; a hydraulic control circuit (40, 41) for acting directly on the piston against the mechanical element, in the disengaged position of said clutch (30); and a hydraulic circuit (50, 52, 53, 55, 56) for lubricating and cooling the clutch. The invention can be applied to an engine-transmission unit for motor vehicles.

Abstract: The invention relates to an element comprising an input shaft (37), an output shaft (39), an electric motor (31) comprising a stator (61) and a rotor (63), a first clutch (33) connecting the input shaft (37) and the rotor (63), and a second clutch (35) connecting the rotor (63) and the output shaft (39), said clutches (33, 35) being hydraulic clutches. The transmission element (25) is provided with means for controlling the clutches (33, 35), said means comprising a control fluid circuit (302) and means for bringing (115, 116) at least one of said clutches (33, 35) back into the closed position. The invention also relates to a motor vehicle comprising one such transmission element.