Abstract: Fusion polypeptides have an FGFR2 polypeptide and cDNAs encode such fusion polypeptides. Methods of diagnosing the presence of the fusion polypeptides or of a gene or RNA sequence coding therefore in a sample from a subject as well as methods of treatment of a tumor instructed by the latter diagnosis.

Abstract: Fusion polypeptides have an FGFR2 polypeptide and cDNAs encode such fusion polypeptides. Methods of diagnosing the presence of the fusion polypeptides or of a gene or RNA sequence coding therefore in a sample from a subject as well as methods of treatment of a tumor instructed by the latter diagnosis.

Abstract: The present invention relates to the use of genetic markers to identify the response to growth hormone treatment in Growth Hormone Deficiency (GHD) or Turner Syndrome (TS) patients as well as a method of treating GHD or TS patients and kits for genotyping.

Abstract: The present invention relates to the use of genetic markers to identify the response to growth hormone treatment in Growth Hormone Deficiency (GHD) or Turner Syndrome (TS) patients as well as a method of treating GHD or TS patients and kits for genotyping.

Abstract: The present invention relates to the use of SNPs in predicting susceptibility and/or severity of Multiple Sclerosis in an individual. The SNPs are located in the introns of the glycosylation enzymes MGAT5 and XYLT1, 3? of HIF1AN, within introns of MEGF11. FGF14, PDE9A and CDH13 and within desert regions of 4q34 and 17p13.

Abstract: The invention relates to a method of genotyping and for predicting the susceptibility for SLE and/or MS by using SNPs related to BANK1 alone or in combination with at least one other SNP.

Abstract: The invention relates to the use of SDF-1, or of an agonist of SDF-1 activity, for the treatment and/or prevention of a neurological disease.

Abstract: An interaction map construction and representation method. References of proteins are represented with links corresponding to alleged interactions between said proteins. A score representing the significance of the protein-protein interaction is determined for each interaction and the scores of the represented interactions are indicated on the interaction map in the vicinity of the interactions to which they correspond.

Abstract: The present invention relates to nucleic acids encoding SID® polypeptides which bind selectively to a polypeptide encoded by a pathogenic strain of the hepatitis C virus, as well as to the SID® polypeptides which are encoded by said nucleic acids. The invention also concerns vectors comprising a nucleic acid encoding a SID® polypeptide as well as host cells transformed with such vectors. The invention is also directed to two-hybrid methods which make use of the nucleic acids encoding a SID® polypeptide selected from a pathogenic strain of the hepatitis C virus as well as to methods for selecting molecules which inhibit the binding between a SID® polypeptide and a polypeptide which specifically binds thereto.

Abstract: A method for organizing genomic and proteomic information in a database having a plurality of data nodes and a plurality of links capable of binding data nodes two by two, genomic and proteomic information being stored in a plurality of independent databases and an access method to access by query the contents of a database organized by the preceding organization method for a defined query. The method uses the steps of: a) organizing of the query in the form of a graph pattern having a plurality of nodes and a plurality of links binding the nodes two by two, the nodes and the links being taken in the set of data node types and links types respectively of the organized database: b) seeking the database of a set of nodes and links whose type corresponding to the query thus organized, the set of nodes and links forming a set of occurrences of the graph pattern; c) provisioning the terminal with the nodes and links.

Abstract: An interaction map construction and representation method in which references of proteins are represented with links corresponding to alleged interactions between said proteins, wherein a score representing the significance of the protein-protein interaction is determined for each interaction and the scores of the represented interactions are indicated on the interaction map in the vicinity of the interactions to which they correspond.

Abstract: Disclosed is a technique to predict protein-protein interaction maps across organisms called an “interacting-domain profile pair” method. The method uses a high-quality protein interaction map with interaction domain information as input to predict an interaction map in another organism. It combines sequence similarity searches with clustering based on interaction patterns and interaction domain information. Results can be compared with predictions from a naive inference method based only on full-length protein sequence similarity. This domain-based method can eliminate a significant amount of false-positives compared to methods that are the consequences of multi-domain proteins; as well as increase the sensitivity by identifying new potential interactions.

Abstract: The present invention relates to nucleic acids encoding SID® polypeptides which bind selectively to a polypeptide encoded by a pathogenic strain of the hepatitis C virus, as well as to the SID® polypeptides which are encoded by said nucleic acids.