Abstract: Methods, computing entities, systems, and computer program products for monitoring alertness of an operator of a vehicle are provided. In an example embodiment, a mobile computing entity receives biometric data and behavior data for the operator. The biometric data and behavior data captured by at least one of a wearable sensor, a visual sensor, or a vehicle sensor onboard the vehicle. The mobile computing entity determines an alertness level of the operator based at least in part on the biometric data and the behavior data using a model that is personalized for the operator. Responsive to determining that the alertness level of the operator satisfies a first treatment level threshold, the mobile computing entity initiates an operator engagement interaction to increase the alertness level of the operator.