Abstract: A protective sheath for a bronchoscope is provided, comprising a flexible and collapsible sleeve having a first open end and a second open end; wherein the first open end includes a first resilient member adapted to sealably connect to a bronchoscope control unit; and wherein the second open end includes a second resilient member adapted to sealably connect to an adapter device for receiving the bronchoscope. The sleeve is constructed from a nonpermeable, collapsible, and food grade plastic. A suction port is preferably attached to the sleeve adapted to fluidically remove air and fluids from the sleeve during the bronchoscopy procedure.