Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.

Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.

Abstract: A nonwoven web product including ultra-fine fibers is formed utilizing a spunbond apparatus that forms multicomponent fibers by delivering first and second polymer components in a molten state from a spin pack to a spinneret, extruding multicomponent fibers including the first and second polymer components from the spinneret, attenuating the mulicomponent fibers in an aspirator, laying down the multicomponent fibers on an elongated forming surface disposed downstream from the aspirator to form a nonwoven web, and bonding portions of at least some of the fibers in the nonwoven web together to form a bonded, nonwoven web product. The multicomponent fibers can include separable segments such as islands-in-the-sea fibers, where certain separated segments become the ultra-fine fibers in the web product.

Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.

Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.

Abstract: A nonwoven web product including ultra-fine fibers is formed utilizing a spunbond apparatus that forms multicomponent fibers by delivering first and second polymer components in a molten state from a spin pack to a spinneret, extruding multicomponent fibers including the first and second polymer components from the spinneret, attenuating the multicomponent fibers in an aspirator, laying down the multicomponent fibers on an elongated forming surface disposed downstream from the aspirator to form a nonwoven web, and bonding portions of at least some of the fibers in the nonwoven web together to form a bonded, nonwoven web product. The multicomponent fibers can include separable segments such as islands-in-the-sea fibers, where certain separated segments become the ultra-fine fibers in the web product.

Abstract: A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate is solubilized with an echinocandin compound or echinocandin/carbohydrate complex in a solvent(s) to form a pharmaceutical solution which is sprayed onto the surface of a granular diluent or carrier. The resulting granular oral formulations and medicaments derived therefrom are also described.

Abstract: A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate is solubilized with an echinocandin compound or echinocandin/carbohydrate complex in a solvent(s) to form a pharmaceutical solution which is sprayed onto the surface of a granular diluent or carrier. Alternatively, a granulating agent is added to the pharmaceutical solution which is then sprayed onto the surface of a non-granular diluent or carrier. The resulting granular oral formulations and medicaments derived therefrom are also described.

Abstract: A fastening track, a cot transport vehicle adapted to securely receive the fastening track, and a cot fastening system incorporating the cot fastening track are provided. At least two track securing members extend from the lower surface of the fastening track and are received in a self-centering aperture of a mounting assembly provided within a support surface of a transport vehicle. The fastening track comprises a frame including a spanner which is resistant to thermal expansion. A locking mechanism is provided including a convenient a latch disengagement member. The fastening track also includes a track clamping mechanism comprising a safety flag movable between a secured position and an unsecured position. The safety flag prevents inadvertent disengagement of the track from the vehicle and improper loading of a cot onto the vehicle. A stop cam is provided on the track to prevent inadvertent unloading of the cot from the track.

Abstract: An automatic ski rope rewinding device is presented used to rewind a ski rope when the rope is not pulling a skier. The invention utilizes a standard rope or cord rewinding mechanism which is mounted by L-shaped brackets to the body of the boat. The rewinding mechanism and rope are encased by an outer, waterproof casing. A water removing gasket facilitates removal of water from a rope being rewound and a loop near the attached end of the ski rope is used to directly attach the ski rope to the boat cleat when pulling a skier.

Abstract: Empty wafer cassettes are stored on a transfer stand having one or more storage locations on a post which extends below a wafer comb while the wafers are being processed. Each storage location generally has a cross bar with spaced upward projections for receiving the leg of a cassette.

Abstract: A gas scavenger unit educts gases away from semiconductor wafers as they are withdrawn through a plenum in the scavenger from their processing chamber into the atmosphere. The scavenger has a peripheral wall which generally defines a plenum having two open ends. The one end of the plenum communicates with the processing chamber and the other end communicates with the atmosphere. An exhaust port in the peripheral wall communicates with a house gas exhaust system. The plenum is divided into two chambers by an apertured interior wall. The wafers travel through the first chamber, and the second chamber communicates with the house gas exhaust system. The apertures in the interior wall are disposed about the wafer travel path so that gases from the processing chamber and/or the atmosphere are educted into the house exhaust system without flowing across the wafers.

Abstract: An open-topped container is constructed with a plurality of compartments, each having its own discharge opening and each having its own liner of the type that can be selectively rolled up or unrolled according to loading and unloading operations. Each liner is connected to its own biasing means which is effective to yield and lower the liner as the compartment is loaded and effective to recover to elevate the liner to facilitate unloading, all for the purpose of handling material, such as fruits and vegetables and the like, in such a way as to eliminate or at least minimize damage thereto.

Abstract: A hydrostatic drive system for a four wheel drive vehicle such as a field harvesting machine which must accurately track the planting rows, includes an engine, a pump and individual hydraulic wheel motors connected to the pump and coupled to the wheels through a manually set free wheeling clutch. The motors are in series connection at each side of the vehicle, with the pairs of series connected motors on opposite sides of the vehicle in parallel connection with the pump. When the traction of a wheel on one side is reduced or lost, both wheels on that side continue to rotate at the same speed. Under these conditions, the driving wheel motor on the aforesaid side of the vehicle will provide increased torque output to compensate for the reduced driving power of the slipping wheel.

Abstract: A row crop harvester is provided with mechanism for mounting two picking heads for both vertical and horizontal adjustment of the ground engaging lower ends of the heads, to simultaneously harvest two rows of plants which may vary in spacing from each other throughout their lengths. One head is guided along its row by steering the harvester itself, while the lower end of the other head is guided along its row by selectively operating controls which transversely shift the lower end of the head relative to the first mentioned steerable head thereby accurately following and simultaneously harvesting two rows of crops such as root crops.In the preferred embodiment the upper end of each picking head is associated with a severing mechanism for removing the tops or foliage from the roots of the plants.

Abstract: A machine for guiding melons from the ground onto lifting and distributing conveyors, having a fence for guiding melons along the ground toward a lift wheel which is rotating about a substantially horizontal axis, the wheel having flexible fingers extending radially therefrom to sweep the melons toward an upwardly inclined conveyor belt.