Patents by Inventor Jerry A. Walker
Jerry A. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140312124Abstract: An RFID assembly for securing an RFID device to a container. The assembly includes a clip having a first leg and a second leg connected by a resiliently flexible byte portion. The RFID device is attached to the clip. The assembly is inserted under and within an upper rim of a container, and the spring force provided by the byte portion secures the clip within the space, hidden from view. The first and/or second legs may include teeth to assist in securing the assembly in position.Type: ApplicationFiled: July 7, 2014Publication date: October 23, 2014Inventors: Jerry A. Walker, R. Michael Lewis, Bryan L. Schierbeek, John E. Misner, Kevin A. Bull
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Publication number: 20140047681Abstract: An RFID assembly for securing an RFID device to a container. The assembly includes a clip having a first leg and a second leg connected by a resiliently flexible byte portion. The RFID device is attached to the clip. The assembly is inserted under and within an upper rim of a container, and the spring force provided by the byte portion secures the clip within the space, hidden from view. The first and/or second legs may include teeth to assist in securing the assembly in position.Type: ApplicationFiled: August 14, 2012Publication date: February 20, 2014Applicant: CASCADE ENGINEERING, INC.Inventors: Jerry A. Walker, R. Michael Lewis, Bryan L. Schierbeek, John E. Misner, Kevin A. Bull
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Patent number: 4623736Abstract: In preparing arylalkanoic acids, e.g. ibuprofen or naproxen, via the conversion of the selected .alpha.-haloketal derivative of a 1-haloethyl aryl ketone to the haloalkyl ester of the arylalkanoic acid using a zinc salt catalyst the improvement comprising reacting a ring-substituted 6-membered ring ketal of the selected 1-haloethyl C.sub.6 -C.sub.12 -aryl ketone with a soluble zinc carboxylate salt to form the corresponding 3-haloalkyl arylalkanoic acid ester. The ester is converted to the alkali metal salt of the acid with base in an aqueous/water insoluble organic liquid mixture and the crude salt is converted to the corresponding acid in an aqueous/water insoluble solvent mixture for the acid, the organic solution of the acid is washed with a pH 7.0 to 8.Type: GrantFiled: July 9, 1982Date of Patent: November 18, 1986Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Sanjay I. Amin
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Patent number: 4600538Abstract: The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.Type: GrantFiled: August 2, 1984Date of Patent: July 15, 1986Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4568492Abstract: .DELTA.16-20-keto steroids (I) are converted to 17.alpha.-hydroxy-20-keto steroids (III) in 2 steps, hydrosilylation followed by peracid oxidation.Type: GrantFiled: September 14, 1984Date of Patent: February 4, 1986Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4412955Abstract: Disclosed is a 20,21-dihalo steroid (VII) and a steroidal sulfoxide (VIII) as well as processes to produce them. The 20,21-dihalo steroid (VII) and sulfoxide (VIII) are intermediates useful in the preparation of pharmaceutically useful corticoids.Type: GrantFiled: May 17, 1982Date of Patent: November 1, 1983Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Edward J. Hessler
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Patent number: 4411835Abstract: The present invention is a process for the transformation of a 17-keto steroid (II) to a corticoid (XI) which has pharmaceutical utility.Type: GrantFiled: May 17, 1982Date of Patent: October 25, 1983Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Edward J. Hessler
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Patent number: 4404142Abstract: A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).Type: GrantFiled: May 17, 1982Date of Patent: September 13, 1983Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Edward J. Hessler
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Patent number: 4401599Abstract: A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).Type: GrantFiled: May 17, 1982Date of Patent: August 30, 1983Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Edward J. Hessler
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Patent number: 4398035Abstract: The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic acid, known as flurbiprofen, having the formula ##STR1## and ester thereof. It has anti-inflammatory activity which is about 240 times that of aspirin and analgesic activity which is about 180 times that of aspirin in standard laboratory tests. However, despite this high activity, the toxicity (LD.sub.50) is only 1.2 to 2.4 times greater than that of aspirin in standard laboratory tests.Also within the invention is a novel method of making the above intermediates and analogs thereof useful to prepare corresponding biaryl compounds which have pharmaceutical uses.Type: GrantFiled: October 3, 1980Date of Patent: August 9, 1983Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4357279Abstract: A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).Type: GrantFiled: May 18, 1981Date of Patent: November 2, 1982Assignee: The Upjohn CompanyInventors: Jerry A. Walker, Edward J. Hessler
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Patent number: 4342702Abstract: A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C.sub.17 side chain rearrangement.Type: GrantFiled: May 18, 1981Date of Patent: August 3, 1982Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4324904Abstract: The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic acid, known as flurbiprofen, having the formula ##STR1## and ester thereof. It has anti-inflammatory activity which is about 240 times that of aspirin and analgesic activity which is about 180 times that of aspirin in standard laboratory tests. However, despite this high activity, the toxicity (LD.sub.50) is only 1.2 to 2.4 times greater than that of aspirin in standard laboratory tests.Also within the invention is a novel method of making the above intermediates and analogs thereof useful to prepare corresponding biaryl compounds which have pharmaceutical uses.Type: GrantFiled: December 19, 1979Date of Patent: April 13, 1982Assignee: The Upjohn CompanyInventors: Thomas A. Hylton, Jerry A. Walker
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Patent number: 4284827Abstract: Substituted ethanes (I) are reacted with an alkyl metal reagent to form isomeric metalated olefins (IIIA and IIIB) having a trans (IIIB) to cis (IIIA) ratio of greater than 70:30.Type: GrantFiled: December 17, 1979Date of Patent: August 18, 1981Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4266069Abstract: The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic acid, known as flurbiprofen, having the formula ##STR1## and ester thereof. It has anti-inflammatory activity which is about 240 times that of aspirin and analgesic activity which is about 180 times that of aspirin in standard laboratory tests. However, despite this high activity, the toxicity (LD.sub.50) is only 1.2 to 2.4 times greater than that of aspirin in standard laboratory tests.Also within the invention is a novel method of making the above intermediates and analogs thereof useful to prepare corresponding biaryl compounds which have pharmaceutical uses.Type: GrantFiled: December 19, 1979Date of Patent: May 5, 1981Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4226790Abstract: Thallium (l) alkanoate salts are oxidized to thallium (lll) salts in a liquid medium with a peroganic carboxylic acid in the presence of a reactive form of manganese or ruthenium.Type: GrantFiled: August 14, 1978Date of Patent: October 7, 1980Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4142054Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. A continuous process using a Scheibel column is disclosed. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 - to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.Type: GrantFiled: June 16, 1977Date of Patent: February 27, 1979Assignee: The Upjohn CompanyInventors: Sanjay I. Amin, Jerry A. Walker
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Patent number: 4135051Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 - to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.Type: GrantFiled: June 16, 1977Date of Patent: January 16, 1979Assignee: The Upjohn CompanyInventor: Jerry A. Walker
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Patent number: 4107439Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.Type: GrantFiled: June 16, 1976Date of Patent: August 15, 1978Assignee: The Upjohn CompanyInventors: Jerry A. Walker, David R. White, William G. Salmond