Abstract: A hand puncture protector (10) including a pivoting shell which covers susceptible areas on the back and sides of the wearer's thumb (53), index finger (52) and thenar web space to reduce the risk of injury or infection from accidental punctures from needles and other sharp instruments ("SHARPS"). The pivoting shell is formed of a SHARP impervious material, such as thermoplastic, and has separate thumb (11) and index finger (12) components which are preferably fastened together by a single rivet (30) placed above the thenar web space region. VELCRO straps (20, 21) are affixed to the thumb and index finger regions of the molded shell at about the interphalange joint of the thumb and middle phalanx of the index finger to secure the hand protector to the user's hand. A method of protecting health care professionals from injury or infection by accidental punctures is also disclosed.