Patents by Inventor Jerry C. Bommer
Jerry C. Bommer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8859760Abstract: Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.Type: GrantFiled: December 12, 2013Date of Patent: October 14, 2014Assignee: Frontier Scientific, Inc.Inventors: Glenn Prestwich, Jerry C. Bommer, Charles Testa
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Publication number: 20140179742Abstract: Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.Type: ApplicationFiled: December 12, 2013Publication date: June 26, 2014Applicant: Frontier Scientific, Inc.Inventors: Glenn PRESTWICH, Jerry C. BOMMER, Charles TESTA
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Patent number: 8633311Abstract: Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.Type: GrantFiled: July 29, 2009Date of Patent: January 21, 2014Assignee: Frontier Scientific, Inc.Inventors: Jerry C. Bommer, Glenn Prestwich, Charles Testa
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Publication number: 20120016289Abstract: Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.Type: ApplicationFiled: July 29, 2009Publication date: January 19, 2012Applicant: FRONTIER SCIENTIFICInventors: Glenn Prestwich, Jerry C. Bommer, Charles Testa
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Patent number: 7008937Abstract: The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are tetra-positively charged porphyrins based on meso-tetra(4-pyridyl)porphines. Several such agents are shown herein to cause inhibition of iron uptake in vivo and in vitro. The invention further provides therapeutic compositions including the porphyrins and/or metalloporphyrins of the invention. In addition, methods of inhibition of heme iron uptake in vivo are taught, as well as methods of treatment of diseases characterized by iron-overload. These methods include the administration of a porphyrin or metalloporphyrin in a therapeutic composition of the invention to prevent uptake of heme iron, thus preventing replenishment of a patient's iron stores.Type: GrantFiled: June 3, 2004Date of Patent: March 7, 2006Assignee: Frontier Scientific, Inc.Inventor: Jerry C. Bommer
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Publication number: 20040254155Abstract: The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are tetra-positively charged porphyrins based on meso-tetra(4-pyridyl)porphines. Several such agents are shown herein to cause inhibition of iron uptake in vivo and in vitro. The invention further provides therapeutic compositions including the porphyrins and/or metalloporphyrins of the invention. In addition, methods of inhibition of heme iron uptake in vivo are taught, as well as methods of treatment of diseases characterized by iron-overload. These methods include the administration of a porphyrin or metalloporphyrin in a therapeutic composition of the invention to prevent uptake of heme iron, thus preventing replenishment of a patient's iron stores.Type: ApplicationFiled: June 3, 2004Publication date: December 16, 2004Inventor: Jerry C. Bommer
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Patent number: 6573258Abstract: A series of novel positively-charged porphyrins is disclosed which exhibit a markedly increased efficiency in photosensitizing both Gram-positive and Gram-negative bacteria to the action of visible light, causing death to such bacteria when present at much lower concentrations and much shorter irradiation times than those porphyrins taught in the prior art. These porphyrins are characterized by the presence of up to four positive charges in the peripheral substituents and at least one hydrophobic tail comprising between 6 and 22 carbons inclusive, originating at one or more of the charged sites.Type: GrantFiled: September 26, 2001Date of Patent: June 3, 2003Assignee: Frontier Scientific, Inc.Inventors: Jerry C. Bommer, Giulio Jori
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Publication number: 20030050296Abstract: A series of novel positively-charged porphyrins is disclosed which exhibit a markedly increased efficiency in photosensitizing both Gram-positive and Gram-negative bacteria to the action of visible light, causing death to such bacteria when present at much lower concentrations and much shorter irradiation times than those porphyrins taught in the prior art. These porphyrins are characterized by the presence of up to four positive charges in the peripheral substituents and at least one hydrophobic tail comprising between 6 and 22 carbons inclusive, originating at one or more of the charged sites.Type: ApplicationFiled: September 26, 2001Publication date: March 13, 2003Applicant: Frontier Scientific, Inc.Inventors: Jerry C. Bommer, Giulio Jori
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Patent number: 5169944Abstract: Hepatobiliary magnetic resonance imaging of a human or animal subject is enhanced by enterally administering to the subject an effective amount of a lipophilic contrast enhancing agent. Representative contrast enhancing agents include manganese mesoporphyrin, manganese deuteroporphyrin, manganese pheophorbide and manganese pyrophenophoribide, and, when administered orally, an enteric delivery agent.Type: GrantFiled: April 12, 1991Date of Patent: December 8, 1992Assignee: Board of Regents of the University of WashingtonInventors: James A. Nelson, Udo P. Schmiedl, Linnar L. Teng, Jerry C. Bommer
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Patent number: 5066274Abstract: This invention relates to a therapeutic composition for detection and/or treatment of mammalian tumors which comprises at least one fluorescent porphyrin containing at least three carboxylic acid groups and pharmaceutically acceptable salts thereof.Type: GrantFiled: May 12, 1989Date of Patent: November 19, 1991Assignee: Nippon Petrochemicals Company, Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham
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Patent number: 5004811Abstract: A fluorescent mono-, di-, or tri- or tetramide between an amino acid of the formula ##STR1## and a carboxy containing tetrapyrrole of the formula: ##STR2## or the corresponding di or tetrahydrotetrapyrroles. The compounds herein are useful for the photodetection and phototreatment of tumors and/or cancerous tissues in animal hosts.Type: GrantFiled: December 24, 1987Date of Patent: April 2, 1991Assignee: Nippon Petrochemicals Company, Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham
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Patent number: 4977177Abstract: This invention relates to new therapeutic compositions which are useful in photodiagnosis and phototherapy, especially in the detection and treatment of tumors and cancerous tissues in the human or animal body. The compounds of the present new therapeutic composition are mono-, di or polyamides of an amino monocarboxylic acid and a tetrapyrrole containing at least one carboxyl group of the structure ##STR1## wherein Z is the aminomonocarboxylic acid residue less the amino group, X is the tetrapyrrole residue less the carboxy group, and "n" is an integer from 1 to 4 inclusive.Type: GrantFiled: April 30, 1985Date of Patent: December 11, 1990Assignee: Nippon Petrochemicals Company, Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham
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Patent number: 4693885Abstract: This invention relates to a fluorescent mono, di- or polyamide of an aminodicarboxylic acid and a tetrapyrrole containing at least three carboxy groups of the structure: ##STR1## wherein Z is the amino acid residue and X is the tetrapyrrole residue and "n" is an integer from 1 to 4 inclusive.Type: GrantFiled: April 30, 1985Date of Patent: September 15, 1987Assignee: Nippon Petrochemicals Co., Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham
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Patent number: 4675338Abstract: The present invention relates to compounds having the following formula: ##STR1## or the corresponding di- or tetrahydrotetrapyrroles wherein ##STR2## provided that when R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 represent two substituents or are divalent and attached to the same carbon, the respective pyrrole ring to which attached is a dihydropyrrole;R is lower alkyl or benzyl;R.sub.6 and R.sub.9, taken together are ##STR3## with the proviso that at least one of R.sub.1 -R.sub.9 includes a free carboxyl group; and salts thereof.These compounds are useful in the photodiagnosis and phototherapy of tumors.Type: GrantFiled: July 18, 1984Date of Patent: June 23, 1987Assignee: Nippon Petrochemicals Co., Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham
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Patent number: 4656186Abstract: This invention relates to new fluorescent mono, di- or polyamide of an aminomonocarboxylic acid and a tetrapyrrole containing at least three carboxy groups of the structure: ##STR1## wherein Z is the amino acid residue and x is the tetrapyrrole residue and "n" is an integer from 1 to 4 inclusive.Type: GrantFiled: April 30, 1985Date of Patent: April 7, 1987Assignee: Nippon Petrochemicals Co., Ltd.Inventors: Jerry C. Bommer, Bruce F. Burnham