Abstract: Devices, systems and methods for monitoring patient adherence to treatment regimens are described herein. In some embodiments, a medication dispensing system includes a medication dispensing device and a monitor. The medication dispensing device is configured to receive dose containers, and includes a dispensing mechanism that is operable to dispense at least one of the dose containers at a predetermined time based on a prescribed treatment regimen. Each of the dose containers defines an interior region configured to contain a plurality of individual medications. The medication dispensing device also includes an event detection system including a plurality of sensors configured to detect a change in status of the medication dispensing device and/or a change in the dose containers, and a control unit configured to operate the dispensing mechanism and the event detection system, and to communicate with a monitor (e.g., a remote server or any third-party monitor) and a user.