Patents by Inventor Jerry D. Glickson

Jerry D. Glickson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antineoplastic agents targeted via glut transporters
    Patent number: 7943586
    Abstract: The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: May 17, 2011
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gang Zheng, Jerry D. Glickson, Britton Chance
  • Antineoplastic Agents Targeted via Glut Transporters
    Publication number: 20080269112
    Abstract: The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neoplastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The inventions also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
    Type: Application
    Filed: February 6, 2008
    Publication date: October 30, 2008
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Gang Zheng, Jerry D. Glickson, Britton Chance
  • Lipoprotein-Based Nanoplatforms
    Publication number: 20080253960
    Abstract: The present invention provides a non-naturally occurring lipoprotein nanoplatform (“LBNP”) comprising at least one cell surface receptor ligand; at least one lipoprotein; and at least one diagnostic agent and/or at least one therapeutic agent. In embodiments of the present invention, the cell surface receptor ligand is not a low-density lipoprotein receptor ligand and the cell surface receptor ligand is covalently bonded to the apoprotein. The present invention also provides pharmaceutical formulations comprising LBNPs and methods of making the LBNPs.
    Type: Application
    Filed: April 1, 2005
    Publication date: October 16, 2008
    Applicant: The Trustees of the University of Pennsylvania Center for Technology Transfer
    Inventors: Gang Zheng, Jerry D. Glickson
  • ACTIVATABLE PHOTODYNAMIC THERAPY AGENTS
    Publication number: 20080193431
    Abstract: The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodynamic therapy agents. The invention further relates to methods for decontaminating blood and methods for treating cancer or viral infection in a subject using the conjugates of the present invention.
    Type: Application
    Filed: May 15, 2006
    Publication date: August 14, 2008
    Applicant: University of Pennsylvania
    Inventors: Gang Zheng, Jerry D. Glickson, Britton Chance, Edward James Delikatny, Klara Stefflova, Juan Chen