Abstract: An air sanitization and purification system controlled by a thermostat in wired or wireless communication with an ultraviolet germicidal irradiation light or bipolar ionization appliance, with operation of the light or appliance controlled according to a pre-defined operation schedule of a heating, ventilation and cooling (HVAC) system or by receipt of sensor data indicating the presence of a person with an enclosed area heated or cooled by the HVAC system.