Abstract: An ophthalmic formulation, comprising a chelator (such as EDTA and its salts), and a transport enhancer (such as Methyl Sulfonyl Methane; MSM) and an effective amount of a viscoelastic polymer (such as hydroxymethyl cellulose; HEC) is provided. Together, the combination of the two substances unexpectedly and beneficially reduces discomfort associated with and increases efficacy of chelator/transport enhancer as compared to formulations without the viscoelastic polymer.

Abstract: An anti-microbial composition, comprising a chelator (such as EDTA and its salts), and a transport enhancer (such as Methyl Sufonyl Methane; MSM) is provided. Together, the combination of the two substances unexpectedly and beneficially inhibits bacterial or fungal biofilms when administered to an area of microbial infection. Preferred formulations include spray, lotion, solution, gel, cream, ointment, soap, deodorant, surgical rinse, or dental rinse.

Abstract: Methods and formulations are provided for the treatment of localized edema, particularly localized edema resulting from chronic venous insufficiency. A metal ion sequestrant is topically administered to a subject afflicted with localized edema in combination with a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide. Topically administrable formulations for use in the aforementioned method are also provided.

Abstract: An anti-microbial composition, comprising a chelator (such as EDTA and its salts), and a transport enhancer (such as Methyl Sufonyl Methane; MSM) is provided. Together, the combination of the two substances unexpectedly and beneficially inhibits bacterial or fungal biofilms when administered to an area of microbial infection. Preferred formulations include spray, lotion, solution, gel, cream, ointment, soap, deodorant, surgical rinse, or dental rinse.

Abstract: An anti-microbial composition, comprising a chelator (such as EDTA and its salts), and a transport enhancer (such as Methyl Sufonyl Methane; MSM) is provided. Together, the combination of the two substances unexpectedly and beneficially inhibits bacterial or fungal biofilms when administered to an area of microbial infection. Preferred formulations include spray, lotion, solution, gel, cream, ointment, soap, deodorant, surgical rinse, or dental rinse.

Abstract: An antiplaque oral composition, such as a toothpaste, gel dentifrice, tooth powder, mouth-rinse or mouthwash, tooth hardener, anti-calculus composition, gum or lozenge, comprising a chelator (such as EDTA and its salts), and a transport enhancer (such as Methyl Sulfonyl Methane; MSM) are provided. Together, the combination of the two substances unexpectedly and beneficially removes dental plaque when brushed or applied on teeth and gums. Preferred compositions are toothpastes, gel dentifrices and mouth-rinses or mouthwashes. Also provided are processes of repeatedly applying such antiplaque oral compositions to the teeth to obtain the antiplaque benefits mentioned.

Abstract: Oral formulations are provided for prevention and treatment of adverse oral conditions such as gingivitis, periodontal disease, removal of calculus to improve dental hygiene, and control of dental plaque and biofilm. Use of the formulations for prevention and treatment of other adverse oral conditions including inflammation and oxidative and/or free radical damage within the oral cavity are provided. Treatable conditions may relate to other conditions or diseases, including diabetes, AIDS and cancer. Oral formulations containing a biocompatible chelating agent, and a permeation enhancer such as methylsulfonylmethane (MSM) are disclosed. Components of the formulations are multifunctional and Generally Regarded As Safe.

Abstract: The software site licensing system includes a client site having a target unit and a license sales site for generating a corresponding site license. The sales site receives an order for a target unit from the client and sends the physical order to a warehouse for shipping. The sales site determines the intangible portion of the order and establishes a virtual warehouse for the client to inventory the intangibles (license components). The warehouse notifies the sales site of the unique identifiers on the target prior to shipping so the sales site can link the en-route target with the client. The client accesses its personal virtual warehouse and selects the license components desired for the site license. The system assembles the site license and upon request, transmits the site license from the virtual warehouse to the target unit for installation.

Abstract: Apparatuses and methods assist in mobility of a person. According to an embodiment of the invention, a device for enhancing mobility of a physically-impaired person comprises: a first member that comprises an elongated portion; and a second member that is configured to slidably receive the elongated portion of the first member and to have negative draft relative to the elongated portion of the first member. According to another embodiment of the invention, there is a method for producing an apparatus for assisting in ambulation. The method comprises the steps of: providing a first member that comprises an elongated portion; and providing a second member, including: forming a recess in the second member for slidably receiving the elongated portion of the first member; and tapering the recess to have negative draft relative to the elongated portion of the first member.

Abstract: An method and formulation are provided for the prevention and treatment of adverse ocular conditions which are complications of diabetes. In one embodiment, the invention comprises administering to a person having diabetes, insulin resistance, or a risk factor for diabetes a formulation comprising a metal chelator and a transport enhancer. Most preferably, the metal chelator is EDTA or a salt of EDTA, and the transport enhancer is methylsulfonylmethane (MSM). The formulation may be in a form suitable for application to the eye itself, for example, in the form of eye drops.

Abstract: An ophthalmic formulation is provided for the prevention and treatment of adverse ocular conditions, including presbyopia, arcus senilis, age-related macular degeneration, and other conditions associated with aging. The formulation is also useful in the prevention and treatment of other adverse ocular conditions such as those associated with oxidative and/or free radical damage within the eye; these conditions can involve a condition, disease, or disorder of the cornea, retina, lens, sclera, anterior segment, or posterior segment of the eye. In one embodiment, the formulation contains at least 0.6 wt. % of a biocompatible chelating agent, an effective permeation enhancing amount of an ophthalmic permeation enhancer such as methylsulfonylmethane (MSM), an anti-AGE agent, i.e., a compound that serves to reduce the presence of advanced glycation endproducts (AGEs) in the eye, and a pharmaceutically acceptable ophthalmic carrier suited to the particular formulation type (e.g., eye drops or ointments).

Abstract: A method and formulation are provided for the administration of ophthalmologically active agents. In one embodiment, the method and formulation provided are for the treatment of medical conditions associated with the formation and/or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. In another embodiment, the method and formulation provided are for the treatment of ocular conditions and disorders associated with aging.

Abstract: A method and formulation are provided for the treatment of medical conditions associated with the formation and/or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. The formulation contains a non-cytotoxic chelating agent containing at least three negatively charged chelating atoms and a charge-masking agent containing at least one polar group and having a molecular weight of less than about 250, wherein the polar group contains at least one and preferably at least two heteroatoms having a Pauling electronegativity greater than about 3.00, and further wherein the molar ratio of the charge-masking agent to the chelating agent is sufficient to ensure that substantially all negatively charged chelating atoms are associated with a heteroatom on the charge-masking agent.

Abstract: The software site licensing system includes a client site having a target unit and a license sales site for generating a corresponding site license. The sales site receives an order for a target unit from the client and sends the physical order to a warehouse for shipping. The sales site determines the intangible portion of the order and establishes a virtual warehouse for the client to inventory the intangibles (license components). The warehouse notifies the sales site of the unique identifiers on the target prior to shipping so the sales site can link the en-route target with the client. The client accesses its personal virtual warehouse and selects the license components desired for the site license. The system assembles the site license and upon request, transmits the site license from the virtual warehouse to the target unit for installation.

Abstract: According to an embodiment of the invention, an apparatus for assisting ambulation comprises: a first member; a second member adjustably connected to the first member, the first and second members together spanning an adjustable height; and at least one tab, integrally formed on the first member, that, when engaged, opposes adjustment of the adjustable height. According to another embodiment, a method for producing an apparatus for assisting in mobility comprises: forming a first member including integrally forming a stop on the first member, wherein the stop is not merely a bore through the first member; providing a second member; and adjustably connecting the second member to the first member, wherein the first and second members together span an adjustable height, and wherein the stop is configured as capable of being engaged to oppose relative motion against the second member to thereby oppose adjustment of the adjustable height.

Abstract: Apparatuses and methods assist in mobility of a person. According to an embodiment of the invention, a device for enhancing mobility of a physically-impaired person comprises: a first member that comprises an elongated portion; and a second member that is configured to slidably receive the elongated portion of the first member and to have negative draft relative to the elongated portion of the first member. According to another embodiment of the invention, there is a method for producing an apparatus for assisting in ambulation. The method comprises the steps of: providing a first member that comprises an elongated portion; and providing a second member, including: forming a recess in the second member for slidably receiving the elongated portion of the first member; and tapering the recess to have negative draft relative to the elongated portion of the first member.

Abstract: Apparatuses and methods assist in mobility of a person. According to an embodiment of the invention, an apparatus for assisting in mobility of a person comprises: a crutch having a crutch length along an axis; and at least two adjustment points on the crutch, wherein the length is adjustable at the adjustment points, whereby the crutch is customizable for accommodating body dimensions of an intended user; wherein the adjustment points include a first and a second adjustment point, and the first adjustment point is configured to, at least occasionally, contribute an adjustment to the crutch length that is not merely an adjustment that is being contributed by the second adjustment point.

Abstract: According to an embodiment of the invention, an mobility-aid apparatus comprises: a first member that includes an exterior, a second member adjustably connected to the first member, and a lock. The first member is made using a mold that includes at least a first form unit that forms a first portion of the exterior and a second form unit that forms a second portion of the exterior. There is at least one boundary on the exterior between the first and second portions. The first and second members together span an adjustable axial length. The lock fixes the adjustable axial length against at least one of contraction or expansion, wherein the lock engages, or exists on, the first member not on the at least one boundary on the exterior of the first member. According to an embodiment of the invention, a method is for producing an apparatus for assisting in mobility.

Abstract: An underarm crutch according to an embodiment comprises an underarm support that is placed underarm of a person during use; and at least one elongated member that bears weight and that includes a polymeric material as a structural basis, wherein the underarm support is coupled to the at least one member to help support weight of the person; wherein the underarm crutch has height during use, a substantial portion of which height is contributed by the at least one elongated member; and wherein the underarm crutch comprises substantially no metal, whereby the underarm crutch is capable of not triggering an alarm by an airport metal detector. An apparatus according to another embodiment comprises: a crutch that is substantially composed of injection molded plastic and that includes no metal; wherein the crutch, when viewed using x-ray, has appearance that differs from appearance of a metal crutch.

Abstract: An improved Schirmer I Tear Test is provided. The improvement comprises a strip having a graduated migration scale printed on the test strip and the presence of a water soluble marker dye that comigrates with the tear migration front. Both improvements serve to increase the reproducibility of the test and ease which with the results are read.