Abstract: Systems and methods are provided for combining predictive analytics with a cutting-edge electrochemical sensor having specialized coatings designed to reduce biofouling to (1) monitor drug concentration data of a patient in real-time; and (2) predict future pharmacokinetic parameters for the patient more accurately than existing technologies. Embodiments may construct highly accurate and patient-specific pharmacokinetic models which can dynamically adjust predictions of future pharmacokinetic parameters as they receive real-time drug concentration data from the electrochemical sensor. Certain embodiments may automatically adjust administration of a drug to a patient based on the aforementioned predictions and pharmacokinetic models. Other embodiments may provide a notification to a clinician containing, e.g., a recommended course of drug administration before a patient is woken up.